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Synthesis of Some Benzimidazole-Thiophene Hybrids as Potential Urease and Lipase Inhibitors

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Abstract

In this study, some benzimidazole-thiophene hybrid compounds containing isatin and salicyl moieties were synthesized and investigated for their urease and lipase inhibition properties. Most of the synthesized compounds were found to show effective antiurease activities, when compared with standard Thiourea (0.5027 ± 0.0293 µM). The synthesized isatin containing hybrids (IVa–IVc) showed antiurease inhibitory activities ranging from 0.411 ± 0.0337 to 0.431 ± 0.0446 µM, while IC50 of standard thiourea was 0.5027 ± 0.0293 µM. The general of salicyl containing hybrids showed low antiurease inhibitory activities, while compound (Ve) showed 0.338 ± 0.0387 µM activity. The lipase inhibition activities of the synthesized hybrid molecules showed the activities ranging from 0.287 ± 0.0341 to 0.912 ± 0.0832 µM, while the standard Orlistat showed 0.21 ± 0.012 µM activity. In the light of the information obtained from this study, the results showed that the synthesized hybrid compounds could be potential antilipase and antiurease agents.

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ACKNOWLEDGMENTS

The authors thank all the colleagues in the project unit for this support.

Funding

This work was supported by Research Fund of Recep Tayyip Erdogan University under the Project Number of FBA-2020-1071.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Process Technology, Vocational School of Technical Sciences, Recep Tayyip Erdogan University, 53100, Rize, Turkey

    Fatih Yilmaz

  2. Department of Chemistry, Faculty of Art and Sciences, Recep Tayyip Erdogan University, 53100, Rize, Turkey

    Emre Menteşe

  3. Department of Chemistry, Faculty of Art and Sciences, Giresun University, 28049, Giresun, Turkey

    Bahar Bilgin Sökmen

Authors
  1. Fatih Yilmaz
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  2. Emre Menteşe
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  3. Bahar Bilgin Sökmen
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Contributions

Authors FY and EM designed the experiments, synthesized the molecules and carried out spectral studies. Author BBS carried our biological activity studies.

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Correspondence to Fatih Yilmaz.

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The data that support the findings of this study are available from the corresponding author upon reasonable request. This article does not contain any studies involving animals or human participants performed by any of the authors. Informed consent was not required for this article. No conflict of interest was declared by the authors.

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Yilmaz, F., Menteşe, E. & Sökmen, B.B. Synthesis of Some Benzimidazole-Thiophene Hybrids as Potential Urease and Lipase Inhibitors. Russ J Bioorg Chem 49, 1293–1300 (2023). https://doi.org/10.1134/S1068162023060092

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