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Design, Synthesis and Study of a Novel Antitumor Active Sinomeninylethylenesulfamide

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Abstract

We developed an antitumor compound through a clever one-pot design. Firstly, one end of ethylenediamine was connected to the carbonyl group of sinomenine, then the sulfonamide group was reintroduced and a new sinomeninylethylenesulfamide compound was synthesized. The cell viability of HeLa, HCT-116, McF-7 and L-02 cell lines was determined by sinocine, sinomeninylethylenesulfamide, 5-F and sinomeninylethylenesulfamide+5-F, respectively. The results showed that sinocine sulfa-5-F had better inhibitory effect on HeLa and HCT-116 cell lines, 23.16 ± 4.52 and 21.93 ± 1.07, respectively. Finally, the high binding energy of sinomeninylethylenesulfamide compound and target protein was predicted by molecular simulation docking.

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Funding

This research reported in this publication was supported by the scientific research foundation of Jiangsu University (Grant no. 17JDG002).

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Authors and Affiliations

  1. Department of Clinical Laboratory, Shanghai East Hospital, 200120, Shanghai, China

    H. Yue

  2. Yixing People‘s Hospital, 214200, Yixing, China

    T. Jin & S. Shao

  3. School of Pharmacy, Jiangsu University, 212013, Zhenjiang, China

    G. Jin

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  1. H. Yue
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  2. T. Jin
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  3. S. Shao
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  4. G. Jin
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Correspondence to T. Jin.

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This article does not contain any studies involving animals or human participants performed by any of the authors.

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Yue, H., Jin, T., Shao, S. et al. Design, Synthesis and Study of a Novel Antitumor Active Sinomeninylethylenesulfamide. Russ J Bioorg Chem 48 (Suppl 1), S96–S100 (2022). https://doi.org/10.1134/S1068162023010302

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