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A fragment of the receptor for advanced glycation end products restores the spatial memory of animals in a model of Alzheimer’s disease

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Abstract

The ability of some synthetic peptides modeling the potentially important regions of four membrane proteins, known as cell targets for beta-amyloid, to restore the spatial memory of animals in an experimental model of Alzheimer’s disease has been studied. Nine fragments of the protein receptor for advanced glycation end products (RAGE), which, according to X-ray structure analysis data, repeat all its exposed nonstructural regions, have been synthesized. The effect of these peptides and of earlier synthesized immunoprotective fragments of three other proteins (alpha7-type acethylcholine receptor, the prion protein, and the neurotrophin receptor p75) has been studied on intranasal administration, which excludes the development of the immune response to the peptide. It has been shown that only one fragment, RAGE (60–76), exhibits a therapeutic activity, by restoring the spatial memory of bulbectomized mice and decreasing the level of the brain beta-amyloid.

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Abbreviations

AchR:

alpha7-type acetylcholine receptor

OBE:

olfactory bulb-ectomized

PrP:

prion protein

p75:

neurotrophin receptor

RAGE:

receptor for advanced glycation end products

sRAGE:

the soluble form of RAGE

SO:

sham-operated

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia

    O. M. Volpina, D. O. Koroev, T. D. Volkova, A. V. Kamynina, M. P. Filatova & Ya. V. Zaporozhskaya

  2. Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia

    A. N. Samokhin, I. Yu. Aleksandrova & N. V. Bobkova

Authors
  1. O. M. Volpina
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  2. D. O. Koroev
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  3. T. D. Volkova
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  4. A. V. Kamynina
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  5. M. P. Filatova
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  6. Ya. V. Zaporozhskaya
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  7. A. N. Samokhin
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  8. I. Yu. Aleksandrova
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  9. N. V. Bobkova
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Corresponding author

Correspondence to T. D. Volkova.

Additional information

Original Russian Text © O.M. Volpina, D.O. Koroev, T.D. Volkova, A.V. Kamynina, M.P. Filatova, Ya.V. Zaporozhskaya, A.N. Samokhin, I.Yu. Aleksandrova, N.V. Bobkova, 2015, published in Bioorganicheskaya Khimiya, 2015, Vol. 41, No. 6, pp. 709–716.

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Volpina, O.M., Koroev, D.O., Volkova, T.D. et al. A fragment of the receptor for advanced glycation end products restores the spatial memory of animals in a model of Alzheimer’s disease. Russ J Bioorg Chem 41, 638–644 (2015). https://doi.org/10.1134/S1068162015060187

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  • DOI: https://doi.org/10.1134/S1068162015060187

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