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Application of the Crystal Structure of the SARS-CoV-2 Spike Protein for the Development of a Peptide Vaccine against Virus

  • CRYSTALLOGRAPHY IN BIOLOGY AND MEDICINE
  • Published:
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Abstract

Based on the spike protein of the SARS-CoV-2 virus, a protein capable of causing an immune answer has been predicted. The protein stability in solution is confirmed by the molecular dynamics simulation. Immunomodulation has shown that this protein causes an immune reaction and, correspondingly, may serve a vaccine prototype.

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REFERENCES

  1. J. F.-W. Chan, S. Yuan, K.-H. Kok, et al., Lancet 395 (10223), 514 (2020). https://doi.org/10.1016/S0140-6736(20)30154-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. N. Zhu, D. Zhang, W. Wang, et al., N. Engl. J. Med. 382, 727 (2020). https://doi.org/10.1056/NEJMoa2001017

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. WHO, Coronavirus Disease (COVID-19) Dashboard (World Heal. Organ, 2020).

  4. WHO, Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (2019-nCoV) Infection Is Suspected: Interim Guidance.

  5. G. S. Randhawa, M. P. M. Soltysiak, H. El Roz, et al., PLoS ONE 16 (1), 0232391 (2020). https://doi.org/10.1371/journal.pone.0232391

  6. K. Dongwan, J.-Y. Lee, J.-S. Yang, et al., Cell 181 (4), 914 (2020). https://doi.org/10.1016/j.cell.2020.04.011

    Article  CAS  Google Scholar 

  7. WHO, Draft Landscape of COVID-19 Candidate Vaccines (WHO, Geneva, 2020).

    Google Scholar 

  8. R. F. Smith Trevor, A. Patel, S. Ramos, et al., Nat. Commun. 11, 2610 (2020). https://doi.org/10.1038/s41467-020-16505-0

    Article  ADS  CAS  Google Scholar 

  9. J. Mulligan Mark, K. E. Lyke, N. Kitchin, et al., Nature 586, 589 (2020). https://doi.org/10.1038/s41586-020-2639-4

    Article  ADS  CAS  PubMed  Google Scholar 

  10. F.-C. Zhu, X.-H. Guan, Y.-H. Li, et al., Lancet 396 (10249), 479 (2020). https://doi.org/10.1016/S0140-6736(20)31605-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Q. Gao, L. Bao, H. Mao, et al., Science 369 (6499), 77 (2020).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Y. Cao, A. Yisimayi, F. Jian, et al., Nature 608, 593 (2022). https://doi.org/10.1038/s41586-022-04980-y

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  13. T. M. Gallagher and M. J. Buchmeier, Virology 279 (2), 371 (2001). https://doi.org/10.1006/viro.2000.0757

    Article  CAS  PubMed  Google Scholar 

  14. https://pymol.org/2/

  15. M. J. Abraham, T. Murtola, R. Schulz, et al., SoftwareX 1, 19 (2015). https://doi.org/10.1016/j.softx.2015.06.001

    Article  ADS  Google Scholar 

  16. K. Lindorff-Larsen, S. Piana, K. Palmo, et al., Proteins 78, 1950 (2010). https://doi.org/10.1002/prot.22711

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. H. J. C. Berendsen, J. P. M. Postma, W. F. van Gunsterenvan, et al., J. Chem. Phys. 81 (8), 3684 (1984). https://doi.org/10.1063/1.448118

    Article  ADS  CAS  Google Scholar 

  18. M. Parrinello and A. Rahman, J. Chem. Phys. 76 (5), 2662 (1982). https://doi.org/10.1063/1.443248

    Article  ADS  CAS  Google Scholar 

  19. B. Hess, H. Bekker, J. C. Herman, et al., J. Comput. Chem. 18, 1463 (1997). https://doi.org/10.1002/(SICI)1096

    Article  CAS  Google Scholar 

  20. T. Darden, D. York, and L. Pedersen, J. Chem. Phys. 98 (12), 10089 (1993). https://doi.org/10.1063/1.464397

    Article  ADS  CAS  Google Scholar 

  21. https://kraken.iac.rm.cnr.it/C-IMMSIM/index.php

  22. R. V. Luckheeram, R. Zhou, A. D. Verma, and B. Xia, J. Immunol. Res. 925135 (2012). https://doi.org/10.1155/2012/925135

  23. N. Rapin, O. Lund, M. Bernaschi, and F. Castiglione, PubMed (2010). https://doi.org/10.1371/journal.pone.000986

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Funding

This work was supported by the Ministry of Science and Higher Education of the Russian Federation within the Federal Science and Technology Program for the Development of Synchrotron and Neutron Studies and Research Infrastructure for 2019–2027 (agreement no. 075-15-2021-1355 on October 12, 2021).

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Authors and Affiliations

  1. Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, 119333, Moscow, Russia

    A. S. Ivanovsky, Yu. V. Kordonskaya, M. A. Marchenkova, V. I. Timofeev & Yu. V. Pisarevsky

  2. National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

    I. A. Kolesnikov, Yu. V. Kordonskaya, A. V. Ermakov, M. A. Marchenkova, V. I. Timofeev, Yu. V. Pisarevsky, Yu. A. Dyakova & M. V. Kovalchuk

Authors
  1. A. S. Ivanovsky
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  2. I. A. Kolesnikov
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  3. Yu. V. Kordonskaya
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  4. A. V. Ermakov
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  5. M. A. Marchenkova
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  6. V. I. Timofeev
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  7. Yu. V. Pisarevsky
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  8. Yu. A. Dyakova
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  9. M. V. Kovalchuk
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Corresponding author

Correspondence to A. S. Ivanovsky.

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Translated by Yu. Sin’kov

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Ivanovsky, A.S., Kolesnikov, I.A., Kordonskaya, Y.V. et al. Application of the Crystal Structure of the SARS-CoV-2 Spike Protein for the Development of a Peptide Vaccine against Virus. Crystallogr. Rep. 68, 951–954 (2023). https://doi.org/10.1134/S1063774523601065

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  • DOI: https://doi.org/10.1134/S1063774523601065

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