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Detection of Matrix Metalloproteinases in the Heart of Preterm Rats

  • ANIMAL AND HUMAN PHYSIOLOGY
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Abstract

The influence of preterm birth on the expression of matrix metalloproteinases (MMP2 and MMP9) in the wall of the left ventricle of the rat heart in the early postnatal period of ontogenesis (up to 21 days) was studied. The hearts of preterm (gestation duration 21 and 21.5 days) and term (gestation duration 22 days) Wistar rats on days 7 and 21 of the postnatal period of ontogenesis were studied immunohistochemically in the experiment. Preterm birth has no effect on the pattern of immunohistochemical staining of MMP2 in the wall of the left ventricle of rats, while the content of MMP9 decreases by day 7 and increases by day 21 of the postnatal period of ontogenesis, compared with that of term rats.

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REFERENCES

  1. Bavineni, M., Wassenaar, T.M., Agnihotri, K., Ussery, D.W., Luscher, T.F., and Mehta, J.L., Mechanisms linking preterm birth to onset of cardiovascular disease later in adulthood, Eur. Heart J., 2019, vol. 40, pp. 1107–1112.

    Article  CAS  Google Scholar 

  2. Bellafiore, M., Battaglia, G., Bianco, A., Farina, F., Palma, A., and Paoli, A., The involvement of MMP-2 and MMP-9 in heart exercise-related angiogenesis, J. Transl. Med, 2013, vol. 11, p. 283. https://doi.org/10.1186/1479-5876-11-283

    Article  CAS  Google Scholar 

  3. Blencowe, H., Cousens, S., Oestergaard, M.Z., Chou, D., Moller, A.B., Narwal, R., Adler, A., Vera Garcia, C., Rohde, S., Say, L., and Lawn, J.E., National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications, Lancet, 2012, vol. 379, pp. 2162–2172.

    Article  Google Scholar 

  4. Carr, H., Cnattingius, S., Granath, F., Ludvigsson, J.F., and Edstedt Bonamy, A.K., Preterm birth and risk of heart failure up to early adulthood, J. Am. Coll. Cardiol., 2017, vol. 69, pp. 2634–2642.

    Article  Google Scholar 

  5. Cheng, K.S., Liao, Y.C., Chen, M.Y., Kuan, T.C., Hong, Y.H., Ko, L., Hsieh, W.Y., Wu, C.L., Chen, M.R., and Lin, C.S., Circulating matrix metalloproteinase-2 and -9 enzyme activities in the children with ventricular septal defect, Int. J. Biol. Sci., 2013, vol. 9, pp. 557–563.

    Article  Google Scholar 

  6. Crump, C., Howell, E.A., Stroustrup, A., McLaughlin, M.A., Sundquist, J., and Sundquist, K., Association of preterm birth with risk of ischemic heart disease in adulthood, JAMA Pediatr., 2019, vol. 173, pp. 736–743.

    Article  Google Scholar 

  7. DeCoux, A., Lindsey, M.L., Villarreal, F., Garcia, R.A., and Schulz, R., Myocardial matrix metalloproteinase-2: inside out and upside down, J. Mol. Cell Cardiol., 2014, vol. 77, pp. 64–72.

    Article  CAS  Google Scholar 

  8. DeLeon-Pennell, K.Y., Meschiari, C.A., Jung, M., and Lindsey, M.L., Matrix metalloproteinases in myocardial infarction and heart failure, Prog. Mol. Biol. Transl. Sci., 2017, vol. 147, pp. 75–100.

    Article  CAS  Google Scholar 

  9. Dudley, D.J., Branch, D.W., Edwin, S.S., and Mitchell, M.D., Induction of preterm birth in mice by RU486, Biol. Reprod., 1996, vol. 55, pp. 992–995.

    Article  CAS  Google Scholar 

  10. Falsaperla, R., Lombardo, F., Filosco, F., Romano, C., Saporito, M., Puglisi, F., Piro, E., Ruggieri, M., and Pavone, P., Oxidative stress in preterm infants: overview of current evidence and future prospects, Pharmaceuticals (Basel: Switzerland), 2020, vol. 13, p. 145. https://doi.org/10.3390/ph13070145

    Article  CAS  Google Scholar 

  11. Goss, K.N., Haraldsdottir, K., Beshish, A.G., Barton, G.P., Watson, A.M., Palta, M., Chesler, N.C., Francois, C.J., Wieben, O., and Eldridge, M.W., Association between preterm birth and arrested cardiac growth in adolescents and young adults, JAMA Cardiol., 2020, vol. 5, pp. 910–919.

    Article  Google Scholar 

  12. Huckstep, O.J., Williamson, W., Telles, F., Burchert, H., Bertagnolli, M., Herdman, C., Arnold, L., Smillie, R., Mohamed, A., Boardman, H., McCormick, K., Neubauer, S., Leeson, P., and Lewandowski, A.J., Physiological stress elicits impaired left ventricular function in preterm-born adults, J. Am. Coll. Cardiol., 2018, vol. 71, pp. 1347–1356.

    Article  Google Scholar 

  13. Kandasamy, A.D., Chow, A.K., Ali, M.A., and Schulz, R., Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix, Cardiovasc. Res., 2010, vol. 85, pp. 413–423.

    Article  CAS  Google Scholar 

  14. Lapidaire, W., Clark, C., Fewtrell, M.S., Lucas, A., Leeson, P., and Lewandowski, A.J., The preterm heart-brain axis in young adulthood: the impact of birth history and modifiable risk factors, J. Clin. Med., 2021, vol. 10, no. 6, p. 1285. https://doi.org/10.3390/jcm10061285

    Article  Google Scholar 

  15. Lewandowski, A.J., Levy, P.T., Bates, M.L., McNamara, P.J., Nuyt, A.M., and Goss, K.N., Impact of the vulnerable preterm heart and circulation on adult cardiovascular disease risk, Hypertension, 2020, vol. 76, pp. 1028–1037.

    Article  CAS  Google Scholar 

  16. Maquart, F.X., Pasco, S., Ramont, L., Hornebeck, W., and Monboisse, J.C., An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity. implication in tumor invasion, Crit. Rev. Oncol. Hematol., 2004, vol. 49, pp. 199–202.

    Article  Google Scholar 

  17. Mohamed, A., Marciniak, M., Williamson, W., Huckstep, O.J., Lapidaire, W., McCance, A., Neubauer, S., Leeson, P., and Lewandowski, A.J., Association of systolic blood pressure elevation with disproportionate left ventricular remodeling in very preterm-born young adults: the preterm heart and elevated blood pressure, JAMA Cardiol., 2021, vol. 6, pp. 821–829.

    Article  Google Scholar 

  18. Schulz, C.G., Sawicki, G., Lemke, R.P., Roeten, B.M., Schulz, R., and Cheung, P.Y., MMP-2 and MMP-9 and their tissue inhibitors in the plasma of preterm and term neonates, Pediatr. Res., 2004, vol. 55, pp. 794–801.

    Article  CAS  Google Scholar 

  19. Silva, A.C., Pereira, C., Fonseca, A.C.R.G., Pinto-do-Ó, P., and Nascimento, D.S., Bearing my heart: the role of extracellular matrix on cardiac development, homeostasis, and injury response, Front. Cell Dev. Biol., 2021, vol. 8, p. 621644. https://doi.org/10.3389/fcell.2020.621644

    Article  Google Scholar 

  20. Siwik, D.A. and Colucci, W.S., Regulation of matrix metalloproteinases by cytokines and reactive oxygen/nitrogen species in the myocardium, Heart Fail. Rev., 2004, vol. 9, pp. 43–51.

    Article  CAS  Google Scholar 

  21. Tong, W., Xue, Q., Li, Y., and Zhang, L., Maternal hypoxia alters matrix metalloproteinase expression patterns and causes cardiac remodeling in fetal and neonatal rats, Am. J. Physiol. Heart Circ. Physiol., 2011, vol. 301, pp. H2113–H2121. https://doi.org/10.1152/ajpheart.00356.2011

    Article  CAS  Google Scholar 

  22. Turner, N.A. and Porter, K.E., Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts, IUBMB Life, 2012, vol. 64, pp. 143–150.

    Article  CAS  Google Scholar 

  23. Verzola, R.M.M., Mesquita, R.A., Peviani, S., Ramos, O.H.P., Moriscot, A.S., Perez, S.E.A., and Selistre-de- Araújo, H.S., Early remodeling of rat cardiac muscle induced by swimming training, Braz. J. Med. Biol. Res., 2006, vol. 39, pp. 621–627.

    Article  CAS  Google Scholar 

  24. Walani, S.R., Global burden of preterm birth, Int. J. Gynaecol. Obstet., 2020, vol. 150, pp. 31–33.

    Article  Google Scholar 

  25. Yahalom-Ronen, Y., Rajchman, D., Sarig, R., Geiger, B., and Tzahor, E., Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion, Elife, 2015, vol. 4, p. e07455. https://doi.org/10.7554/eLife.07455

    Article  Google Scholar 

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Funding

This study was supported financially by the “Priority 2030” Strategic Academic Leadership Program.

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Authors and Affiliations

  1. Siberian State Medical University, 634050, Tomsk, Russia

    V. V. Ivanova, I. V. Milto, O. N. Serebryakova & I. V. Sukhodolo

  2. Seversk Biophysical Research Center, 636013, Seversk, Russia

    I. V. Milto

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  1. V. V. Ivanova
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  2. I. V. Milto
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  3. O. N. Serebryakova
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  4. I. V. Sukhodolo
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Correspondence to V. V. Ivanova.

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Conflict of interest. The authors declare that they have no conflicts of interest.

Statement on the welfare of animals. The study protocol was approved by the decision of the Local Ethical Committee of the Siberian State Medical University of the Ministry of Health of Russia No. 8475/1 as of November 30, 2020.

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Translated by L. Solovyova

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Ivanova, V.V., Milto, I.V., Serebryakova, O.N. et al. Detection of Matrix Metalloproteinases in the Heart of Preterm Rats. Biol Bull Russ Acad Sci 49, 671–676 (2022). https://doi.org/10.1134/S1062359022060073

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  • DOI: https://doi.org/10.1134/S1062359022060073

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