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Antioxidants in the Vitreous Body of the Eye of Human Fetuses

  • DEVELOPMENTAL BIOLOGY
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Abstract

Using the method of laser photolysis, we demonstrated the presence of electron-donor antioxidants and determined their total content (not less than 700–1000 µmol/L) in the vitreous body of the human eye in early prenatal development. In the vitreous body, the concentration of uric acid was determined and the presence of catecholamines (dopamine, noradrenaline, and adrenaline), antioxidants with electron-donor properties, was shown. The content of antioxidants in the system of the developing eye, which ensures its redox status, is an important index for assessing the normal state and pathology of the eye and is essential for predicting and interpreting eye diseases in newborns and finding effective approaches to their treatment.

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ACKNOWLEDGMENTS

We are grateful to R.A. Poltavtseva (Kulakov Research Center for Obstetrics, Gynecology, and Perinatology) and M. D. Chibireva (Koltzov Institute of Developmental Biology, Russian Academy of Sciences) for their assistance in this work.

Funding

The work by I.G. Panova was performed under a State Assignment of the Koltzov Institute of Developmental Biology, Russian Academy of Sciences, for 2021 (project no. 0088-2021-0017), and the work by A.S. Tatikolov and P.P. Levin was performed under a State Assignment of the Emanuel Institute of Biochemical Physics, Russian Academy of Sciences (project no. 001201253314).

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Authors and Affiliations

  1. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    I. G. Panova

  2. National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, 117997, Moscow, Russia

    Yu. V. Sukhova & T. Yu. Ivanets

  3. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    A. S. Tatikolov & P. P. Levin

Authors
  1. I. G. Panova
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  2. Yu. V. Sukhova
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  3. A. S. Tatikolov
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  4. P. P. Levin
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  5. T. Yu. Ivanets
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Correspondence to I. G. Panova.

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Conflict of interest. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All protocols for handling human material from autopsy were approved by the Bioethics Commission of the Koltzov Institute of Developmental Biology, Russian Academy of Sciences.

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Translated by M. Batrukova

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Panova, I.G., Sukhova, Y.V., Tatikolov, A.S. et al. Antioxidants in the Vitreous Body of the Eye of Human Fetuses. Biol Bull Russ Acad Sci 48, 662–666 (2021). https://doi.org/10.1134/S1062359021050113

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  • DOI: https://doi.org/10.1134/S1062359021050113

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