Abstract
LncRNAs are involved in a variety of physiological and pathological processes. Whereas, the putative role of lncRNAs in breast cancer remains largely elusive. Herein, we investigated the influence of lncRNA CTBP1-AS2 in breast cancer. The expression of lncRNA CTBP1-AS2 was detected in breast cancer tissues. The possible clinical value of CTBP1-AS2 was evaluated using the Kaplan–Meier curve. The influences of CTBP1-AS2 on tumor cell abilities were determined by in vitro experiments. Online databases and dual-luciferase reporter assay were used to reveal the interaction between CTBP1-AS2, miR-381-3p, and ID1. LncRNA CTBP1-AS2 expression showed rising trend in breast cancer tissues and forecasted a poor survival outcome in breast cancer patients. Functionally, CTBP1-AS2 knockdown inhibited tumor cell growth and invasion in vitro. Mechanistically, CTBP1-AS2 may competitively bind with miR-381-3p and then regulate ID1 to act as a tumor-promoter in breast cancer. Collectively, these results reveal the potential role of lncRNA CTBP1-AS2 in breast cancer and a novel CTBP1-AS2/miR-381-3p/ID1 pathway for tumor progression and suggest that CTBP1-AS2 may be a potential prognostic predictor and therapeutic target for patients with breast cancer.
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This work was supported by Health and Medical Science research topic of Hebei Province (Project no. 20220026).
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HFZ, BL and YHF made substantial contributions to conception and design, acquisition of data, analysis and interpretation of data. JWD and SYZ aided with the planning of the analysis and collected important background information. HFZ draft of the manuscript, YHF revised the manuscript critically for important intellectual content. All authors read and approved the final manuscript.
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Zhou, H.F., Liu, B., Duan, J.W. et al. LncRNA CTBP1-AS2 Influences Cellular Activities via miR-381-3p/ID1 Axis in Breast Cancer. Russ J Genet 59 (Suppl 1), 90–98 (2023). https://doi.org/10.1134/S1022795423130148
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DOI: https://doi.org/10.1134/S1022795423130148