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Genetics of Depressive Disorders: Candidate Genes and Genome-Wide Association Studies

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Abstract

The search for molecular genetic markers of depression has been going on for more than two decades, and it began with molecular studies of the genes of the neurotransmitter systems, primarily serotonin and dopamine. However, for most genes, the results of such studies remain contradictory. In the last decade, a new approach has been used to study the genetics of multifactorial diseases—a genome-wide search for associations. This method made it possible to supplement the list of potential genetic risk factors for depression with new genes that require additional research. The review describes two different approaches to the study of the genetics of depression, as well as current problems and recent advances in this field.

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Funding

The present study was supported by the Russian Foundation for Basic Research (project nos. 19-04-00383, 17-29-02203-ofi-m) and the Program “Postgenomic Technologies and Prospective Solutions in Biomedicine.”

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  1. Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    E. I. Rafikova, A. P. Ryskov & V. A. Vasilyev

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  1. E. I. Rafikova
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  2. A. P. Ryskov
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  3. V. A. Vasilyev
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Correspondence to E. I. Rafikova.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by A. Kazantseva

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Rafikova, E.I., Ryskov, A.P. & Vasilyev, V.A. Genetics of Depressive Disorders: Candidate Genes and Genome-Wide Association Studies. Russ J Genet 56, 903–915 (2020). https://doi.org/10.1134/S1022795420080116

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