Abstract
New biodegradable water/sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/isopropyl myristate (IPM) microemulsion systems for the delivery of medicinal and physiologically active substances are synthesized. The optimum concentrations of components that ensure solubilization of the largest amount of water-soluble substances are selected. The diffusion of model substances (L-lysine, L-serine, glycine, β-alanine) across a membrane is studied. It is found that the rate and pattern of release from the microemulsion vary strongly, depending on the terminal functional groups of amino acids. The effect the hydrophobicity and size of the introduced compounds have on the interaction with components of the transport system is determined using H1 NMR, self-diffusion NMR, the polarized luminescence of laurdan and fluorescein probes, and dynamic light scattering. It is shown that short-chain and polar amino acids are released much more quickly than charged amino acids. The results allow determination of the delivery characteristics of more complex counterparts (e.g., medicinal substances and protein molecules).
Similar content being viewed by others
REFERENCES
J. Ma, X. Song, J. Luo, T. Zhao, et al., Langmuir. 35, 13636 (2019).
M. Ohadi, A. Shahravan, N. Dehghannoudeh, et al., Drug Des. Devel. Ther. 14, 541 (2020).
F. Gre, G. Ragno, R. Muzzalupo, et al., Pharmaceutics 12, 423 (2020).
N. U. Okur, E. S. Cxag, and P. I. Siafaka, J. Ocul. Pharmacol. Ther. 36 (6), 1 (2020).
N. O. Shaparenko, D. I. Beketova, M. G. Demidova, and A. I. Bulavchenko, Russ. J. Phys. Chem. A 92, 948 (2018).
A. Rahdar, P. Taboada, M. R. Hajinezhad, et al., J. Mol. Liq. 277, 624 (2019).
M. A. Saleem, M. F. Nazar, M. Y. Siddique, A. M. Khan, et al., J. Mol. Liq. 292, 111388 (2019).
L. Anil and K. Kannan, J. Pharm. Sci. Res. 10, 16 (2018).
A. Kumar, S. K. Kansal, and A. O. Ibhadonc, Chem. Phys. Lipids 215, 11 (2018).
Y. Poh, S. Ng, and K. Ho, J. Mol. Liq. 273, 339 (2019).
N. B. Pajic, I. Nikolic, E. Mitsou, et al., J. Mol. Liq. 272, 746 (2018).
R. M. Hathout and T. J. Woodman, J. Control Release 161, 62 (2012).
F. F. Lv N. Li, Q. Zheng, et al., Eur. J. Pharm. Biopharm. 62, 288 (2006).
T. Naz, S. Nazir, M. A. Rashid, et al., Pharm. Chem. J. 53, 1047 (2020).
R. M. Hathout, T. J. Woodman, S. Mansour, et al., Eur. J. Pharm. Sci. 40, 188 (2010).
L. Piñeiro, M. Novo, and W. Al-Soufi, Adv. Colloid Interface Sci. 215, 1 (2015).
P. Chong, Biochemistry 27, 399 (1988).
P. Chong, High Press Res. 5, 761 (1990).
M. Amaro, F. Reina, and M. Hof, et al., J. Phys. D: Appl. Phys. 50, 134004 (2017).
E. A. Lissi, E. B. Abuin, M. A. Rubio, and A. Cerón, Langmuir 16, 178 (2000).
A. Amiri-Rigi and S. Abbasi, Food Chem. 197, 1002 (2016).
G. B. Dutt, J. Phys. Chem. B 112, 7220 (2008).
N. G. Arutyunyan, L. R. Arutyunyan, V. V. Grigoryan, and R. S. Arutyunyan, Colloid. J. 70, 666 (2008).
A. Dogrul, A. Arslan, and F. Tirnaksiz, J. Microencapsul. 31, 448 (2014).
A. S. Ivanov, Biomed. Khim. 57, 31 (2011).
C. Salamanca, A. Barrera-Ocampo, J. Lasso, N. Camacho, et al., Pharmaceutics 10, 148 (2018).
B. Lindman and U. Oisson, Ber. Bunsen-Ges. Phys. Chem. 100, 344 (1996).
H. Liu, Y. Wang, Y. Lang, et al., J. Pharm. Sci. 98, 1167 (2009).
M. Fanun, J. Mol. Liq. 133, 22 (2007).
M. Fanun, J. Mol. Liq. 135, 5 (2007).
V. Cojocaru, A. E. Ranetti, L. G. Hinescu, et al., Farmacia 63, 656 (2015).
S. K. Mehta, G. Kaur, and K. K. Bhasin, Pharm. Res. 25, 227 (2008).
N. V. Sautina and Y. G. Galyametdinov, Russ. J. Phys. Chem. A 93, 860 (2019).
N. V. Sautina, A. I. Rybakova, and Y. G. Galyametdinov, Liq. Cryst. Appl. 19, 26 (2019).
N. V. Sautina, A. I. Rybakova, A. T. Gubaidullin, and Y. G. Galyametdinov, Liq. Cryst. Appl. 20 (2), 91 (2020).
M. Kreilgaard, E. J. Pedersen, and J. W. Jaroszewski, J. Control Release 69, 421 (2000).
D. A. Binks, N. Spencer, J. Wilkie, and M. M. Britton, J. Phys. Chem. B 114, 12558 (2010).
F. M. Harris, K. B. Best, and J. D. Bell, Biochim. Biophys. Acta 1565, 123 (2002).
O. I. Volkova, A. A. Kuleshova, B. N. Korvatovskii, and A. M. Saletsky, Opt. Spectrosc. 128, 1975 (2020).
ACKNOWLEDGMENTS
The study was carried out using the equipment of the Center for Collective Use “Nanomaterials and Nanotechnology” of the Kazan National Research Technological University.
Funding
This work was supported by the Russian Foundation for Basic Research, project no. 19-03-00187_A. V.V. Klochkov and D.S. Blokhin are grateful for the subsidy allocated to Kazan Federal University as part of State Task no. 0671-2020-0051 for conducting NMR experiments.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated by M. Timoshinina
Rights and permissions
About this article
Cite this article
Sautina, N.V., Rybakova, A.I., Blokhin, D.S. et al. Effect of Intermolecular Interactions in a Water/AOT/Isopropyl Myristate System on the Release of Biologically Active Substances. Russ. J. Phys. Chem. 95, 2325–2331 (2021). https://doi.org/10.1134/S0036024421110200
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0036024421110200