Abstract
A method for obtaining composite medical materials based on polyvinylpyrrolidone (PVP K15) modified with ketoprofen in a medium of supercritical carbon dioxide and with Ag nanoparticles prepared by metal vapor synthesis is developed. A system in which ketoprofen and Ag nanoparticles with an average size of ∼16 nm are uniformly distributed over the bulk of PVP is obtained. It is found that the yield of ketoprofen from the composite in the physiological solution is higher than that for an analogous system obtained by mechanical mixing of the components.
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V. P. Costa, M. E. M. Braga, C. M. M. Duarte, et al., J. Supercrit. Fluids 53, 165 (2010).
V. P. Costa, M. E. M. Braga, J. P. Guerra, et al., J. Supercrit. Fluids 52, 306 (2010).
O. R. Davies, A. L. Lewis, M. J. Whitaker, et al., Adv. Drug Delivery Rev. 60, 373 (2008).
A. Lopez-Periago, A. Argemi, J. M. Andanson, et al., J. Supercrit. Fluids 48, 56 (2009).
L. Manna, M. Banchero, D. Sola, et al., J. Supercrit. Fluids 42, 378 (2007).
M. Banchero, L. Manna, S. Ronchetti, et al., J. Supercrit. Fluids 49, 271 (2009).
C. Erkey, J. Supercrit. Fluids 47, 517 (2009).
E. V. Shtykova, K. A. Dembo, V. V. Volkov, et al., Ross. Nanotekhnol. 4(9), 136 (2009).
L. N. Nikitin, A. Yu. Vasil’kov, A. R. Khokhlov, and V. M. Buznik, Dokl. Akad. Nauk 422, 501 (2008) [Dokl. Chem. 422, 231 (2008)].
A. Yu. Vasil’kov, L. N. Nikitin, A. V. Naumkin, et al., Ross. Nanotekhnol. 4(11–12), 128 (2009).
NIST X-ray Photoelectron Spectroscopy Database, Version 3.5 (National Inst. of Standards and Technology, Gaithersburg, 2003).
DIFFRAC EVA, Bruker-AXS (Madison, WI, USA, 2008).
ICDD, PDF-2/Release (2008).
A. Vasil’kov, A. Naumkin, L. Nikitin, et al., AIP Conf. Proc. 1042, 255 (2008).
S. J. Macnaughton, I. Kikic, N. R. Foster, et al., J. Chem. Eng. Data 41, 1083 (1996).
S. G. Kazarian and G. G. Martirosyan, Int. J. Pharm. 232, 81 (2002).
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Original Russian Text © L.N. Nikitin, A.Yu. Vasil’kov, M. Banchero, L. Manna, A.V. Naumkin, V.L. Podshibikhin, S.S. Abramchuk, M.I. Buzin, A.A. Korlyukov, A.R. Khokhlov, 2011, published in Zhurnal Fizicheskoi Khimii, 2011, Vol. 85, No. 7, pp. 1296–1301.
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Nikitin, L.N., Vasil’kov, A.Y., Banchero, M. et al. Composite materials for medical purposes based on polyvinylpyrrolidone modified with ketoprofen and silver nanoparticles. Russ. J. Phys. Chem. 85, 1190–1195 (2011). https://doi.org/10.1134/S0036024411070223
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DOI: https://doi.org/10.1134/S0036024411070223