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The Reactivity of 3-Hydroxy-6-methyl-2-ethylpyridine 2-Nitroxysuccinate and Reference Drugs in Model NO-Generating Systems

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Abstract

The ability of 3-hydroxy-6-methyl-2-ethylpyridine 2-nitroxysuccinate (I) to generate nitrite ions (\({\text{NO}}_{2}^{ - }\)) and nitrogen monoxide (NO) in model systems with cysteine (Cys) and deoxyhemoglobin (Hb) has been studied. Compound I has been found to release \({\text{NO}}_{2}^{ - }\) and NO more efficiently than Nicorandil. The accumulation rate of \({\text{NO}}_{2}^{ - }\) in the system of Cys with I is by a factor of 1.5 higher than that with Nitroglycerin. It has been shown that, in contrast to Nitroglycerin, compound I is not reduced by Hb.

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Funding

This work was supported by State Contract no. 14.N08.12.0185 of November 2017 “Preclinical study of innovative drugs” under the Federal Research Program “Development of Pharmaceutical and Medical Industry of the Russian Federation until 2020 and for further period” and by State Contract no. 0089–2019–0014.

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Authors and Affiliations

  1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia

    O. V. Pokidova, A. P. Sadkov, A. B. Eremeev, B. S. Fedorov & A. I. Kotelnikov

  2. Ivanovo State University, 153000, Ivanovo, Russia

    E. V. Batova

  3. Moscow State University, 119991, Moscow, Russia

    A. I. Kotelnikov

Authors
  1. O. V. Pokidova
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  2. E. V. Batova
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  3. A. P. Sadkov
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  4. A. B. Eremeev
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  5. B. S. Fedorov
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  6. A. I. Kotelnikov
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Corresponding author

Correspondence to O. V. Pokidova.

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Translated by I. Kudryavtsev

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Pokidova, O.V., Batova, E.V., Sadkov, A.P. et al. The Reactivity of 3-Hydroxy-6-methyl-2-ethylpyridine 2-Nitroxysuccinate and Reference Drugs in Model NO-Generating Systems. Dokl Chem 486, 152–155 (2019). https://doi.org/10.1134/S0012500819060016

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  • DOI: https://doi.org/10.1134/S0012500819060016

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