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A Comprehensive Review on Euphorbiaceae lectins: Structural and Biological Perspectives

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Abstract

Euphorbiaceae, also known as the spurge family, is a large group of flowering plants. Despite being tropical natives, they are now widespread. Due to its medicinal and commercial importance, this family of plants attracted a lot of attention in the scientific community. The distinctive characteristic of the family is production of milky latex, which is a rich source of several lectins, the proteins that bind carbohydrates. Although their function is unclear, they are believed to defend plants against damaging phytopathogenic microorganisms, insects, and predatory animals. Additionally, they serve as crucial metabolic regulators under a variety of stressors. Detection, separation, purification, and characterization of lectins from the Euphorbiaceae family – mostly from the latex of plants – began over 40 years ago. This effort produced over 35 original research papers that were published. However, no systematic review that compiles these published data has been presented yet. This review summarizes and describes several procedures and protocols employed for extraction and purification of lectins belonging to this family. Physicochemical properties and biological activities of the lectins, along with their medicinal and pharmacological properties, have also been analyzed. Additionally, using examples of ricin and ricin agglutinin, we have structurally analyzed characteristics of the lectin known as Ribosome Inactivating Protein Type II (RIP-Type II) that belongs to this family. We anticipate that this review article will offer a useful compendium of information on this important family of lectins, show the scientists involved in lectin research the gaps in our knowledge, and offer insights for future research.

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    Authors and Affiliations

    1. Department of Biotechnology, Africa City of Technology (ACT), Khartoum, Sudan

      Emadeldin Hassan E. Konozy & Makarim Elfadil M. Osman

    2. Pharmaceutical Research and Development Centre, Faculty of Pharmacy, Karary University, Omdurman, Khartoum State, Sudan

      Emadeldin Hassan E. Konozy

    3. Medicinal, Aromatic Plants, and Traditional Medicine Research Institute (MAPTRI), National Center for Research, Khartoum, Sudan

      Amina I. Dirar

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    2. Makarim Elfadil M. Osman
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    3. Amina I. Dirar
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    Contributions

    E.H.E.K. provided the idea and supervised the work, wrote a major part of the initial draft, and revised the final version. M.E.M.O. wrote parts of the first draft, analyzed the structures, and participated in preparation of illustrations. A.I.D. participated in the analysis of structures and preparation of illustrations.

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    Correspondence to Emadeldin Hassan E. Konozy.

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    The authors declare no conflicts of interests in financial or any other spheres. This article does not contain description of studies with involvement of human participants or animals performed by any the authors.

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    Konozy, E.H.E., Osman, M.E.M. & Dirar, A.I. A Comprehensive Review on Euphorbiaceae lectins: Structural and Biological Perspectives. Biochemistry Moscow 88, 1956–1969 (2023). https://doi.org/10.1134/S0006297923110238

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    • DOI: https://doi.org/10.1134/S0006297923110238

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