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Macrophage and Mycobacterium: The war without beginning or end

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Abstract

Mechanisms of macrophage polarization towards M1 phenotype or M2 phenotype, as well as of macrophage transformation into foam cells upon interaction with mycobacteria, are discussed. The possible effects of Mycobacterium tuberculosis (Mtb) on macrophage polarization and activation are analyzed. The role of different cell-death pathways (apoptosis, necrosis, and autophagy) in mycobacteria persistence in vitro and in vivo is elucidated. The most likely means of macrophage reprogramming to increase their microbicidal activity for the purpose of tuberculosis treatment and prevention are analyzed.

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Authors and Affiliations

  1. Research Institute of Experimental and Clinical Medicine, ul. Timakova 2, Novosibirsk, 630117, Russia

    N. K. Zenkov, A. V. Chechushkov, P. M. Kozhin & E. B. Menshchikova

  2. Novosibirsk Research Institute of Tuberculosis, ul. Okhotskaya 81A, Novosibirsk, 630040, Russia

    T. A. Kolpakova

  3. Novosibirsk State Medical University, pr. Krasnyi 52, Novosibirsk, 630091, Russia

    T. A. Kolpakova

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  1. N. K. Zenkov
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  2. A. V. Chechushkov
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  3. P. M. Kozhin
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  5. E. B. Menshchikova
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Correspondence to T. A. Kolpakova.

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Original Russian Text © N.K. Zenkov, A.V. Chechushkov, P.M. Kozhin, T.A. Kolpakova, E.B. Menshchikova, 2015, published in Uspekhi Sovremennoi Biologii, 2015, Vol. 135, No. 6, pp. 554–574.

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Zenkov, N.K., Chechushkov, A.V., Kozhin, P.M. et al. Macrophage and Mycobacterium: The war without beginning or end. Biol Bull Rev 6, 289–308 (2016). https://doi.org/10.1134/S2079086416040095

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