Skip to main content
SpringerLink
Log in

Possible Approaches to Increase the Longevity of Experimental Animals

  • Published:
Advances in Gerontology Aims and scope Submit manuscript

Abstract

A statistically significant difference in the cumulative survival of Wistar rats born in different seasons has been shown: animals born in late November–early December had an average lifespan 24.8% longer, a minimum lifespan 14.3% longer, and a maximum lifespan 20.7% longer in comparison with animals born in April. Transplantation of thymus tissue into the immune privileged anterior chamber of the eye in animals born both in November and April has shown a geroprotective effect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.

Similar content being viewed by others

REFERENCES

  1. Altarev, S.S. and Barabash, O.L., The relationship between the birth season and life expectancy, Klin. Gerontol., 2012, vol. 18, nos. 7–8, pp. 27–30.

  2. Anisimov, V.N., Molekulyarnye i fiziologicheskie mekhanizmy stareniya (Molecular and Physiological Mechanisms of Aging), St. Petersburg: Nauka, 2008.

    Google Scholar 

  3. Vaiserman, A.M., Influence of the birth season on the mortality and longevity of residents of Kiev, Usp. Gerontol., 2002, no. 10, pp. 29–34.

  4. Vinogradova, I.A., Matveeva, Yu.S., Lotosh, T.A., et al., Natural lighting in the north: the inspirer of poets and cancer cells, Materialy II Rossiiskogo simpoziuma s mezhdunarodnym uchastiem “Svetovoi rezhim, starenie i rak,” Petrozavodsk, 17–19 oktyabrya 2013 g. (Proc. II Russ. Symp. with Int. Participation “Light Regime, Aging, and Cancer,” Petrozavodsk, October 17–19, 2013), Kirov: Mezhdunar. Tsentr Nauchno-Issled. Proekt., 2013, pp. 32–40.

  5. Kulikov, A.V., Arkhipova, L.V., Kulikov, D.A., Smirnova, G.N., and Kulikova, P.A., The increase of the average and maximum span of life by the allogenic thymic cells transplantation in the animals’ anterior chamber of eye, Adv. Gerontol., 2014, vol. 4, no. 3, pp. 197–200.

    Article  Google Scholar 

  6. Linkova, N.S., Polyakova, V.O., Trofimov, A.V., Sevostianova, N.N., and Kvetnoy, I.M., Influence of peptides from pineal gland on thymus function with aging, Adv. Gerontol., 2011, vol. 1, no. 3, pp. 240–243.

  7. Khilkov, T.N., Matveeva, Yu.P., Aizikov, D.L., et al., Influence of the disturbance of the light regime in the antenatal and postnatal periods on the lifespan of rat females, Materialy II Rossiiskogo simpoziuma s mezhdunarodnym uchastiem “Svetovoi rezhim, starenie i rak,” Petrozavodsk, 17–19 oktyabrya 2013 g. (Proc. II Russ. Symp. with Int. Participation “Light Regime, Aging, and Cancer,” Petrozavodsk, October 17–19, 2013), Kirov: Mezhdunar. Tsentr Nauchno-Issled. Proekt., 2013, pp. 308–312.

  8. Yakovleva, T.P., Novokhatskaya, E.A., Kalitina, M.A., and Tikhonova, G.I., The season of birth and mortality based on epidemiological studies of worker mortality, Adv. Gerontol., 2016, vol. 6, no. 1, pp. 6–9.

    Article  Google Scholar 

  9. Csaba, G., The immunoendocrine thymus as a pacemaker of lifespan, Acta Microbiol. Immunol. Hung., 2016, vol. 63, no. 2, pp. 139–158.

    Article  CAS  PubMed  Google Scholar 

  10. Csaba, G., The role of the pineal-thymus system in the regulation of autoimmunity, aging and lifespan, Orv. Hetil., 2016, vol. 157, no. 27, p. 1065.

    Article  PubMed  Google Scholar 

  11. Doblhammer, G. and Vaupel, J.W., Lifespan depends on month of birth, Proc. Natl. Acad. Sci. U.S.A., 2001, vol. 98, pp. 2934–2939.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Lerchl, A., Month of birth and life expectancy: role of gender and age in a c16omparative approach, Naturwissenschaften, 2004, vol. 91, no. 9, pp. 422–425.

    Article  CAS  PubMed  Google Scholar 

  13. Pereira, P.A., Millner, T., Vilela, M., et al., Nerve growth factor-induced plasticity in medial prefrontal cortex interneurons of aged Wistar rats, Exp. Gerontol. 2016, vol. 85, pp. 59–70.

    Article  CAS  PubMed  Google Scholar 

  14. Sankar, P., Zachariah, B., Vickneshwaran, V., et al., Amelioration of oxidative stress and insulin resistance by soy isoflavones (from Glycine max) in ovariectomized Wistar rats fed with high fat diet: the molecular mechanisms, Exp. Gerontol., 2015, vol. 63, pp. 67–75.

    Article  CAS  PubMed  Google Scholar 

  15. Taylor, A.W., Ocular immune privilege and transplantation, Front. Immunol., 2016, vol. 7, p. 37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Trivedi, A.K. and Kumar, V., Melatonin: an internal signal for daily and seasonal timing, Indian J. Exp. Biol., 2014, vol. 52, pp. 425–437.

    CAS  PubMed  Google Scholar 

  17. Ueda, P., Edstedt Bonamy, A.-K., Granath, F., and Cnattingius, S., Month of birth and mortality in Sweden: a nation-wide population-based cohort study, PLoS One, 2013, vol. 8, no. 2, p. e56425. https://doi.org/10.1371/journal.pone.0056425.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    A. V. Kulikov & L. V. Arkhipova

  2. Vladimirsky Moscow Regional Research and Clinical Institute, 129110, Moscow, Russia

    P. A. Kulikova, A. A. Glazkov & D. A. Kulikov

Authors
  1. A. V. Kulikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. V. Arkhipova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. A. Kulikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. A. Glazkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. A. Kulikov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. V. Kulikov.

Additional information

Translated by K. Lazarev

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kulikov, A.V., Arkhipova, L.V., Kulikova, P.A. et al. Possible Approaches to Increase the Longevity of Experimental Animals. Adv Gerontol 8, 271–276 (2018). https://doi.org/10.1134/S2079057018040100

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S2079057018040100

Keywords:

Search

Navigation