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The Effect of Сramizol on ApoA1 Gene Expression in Rats with Experimental Hyperlipidemia

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Abstract—

Cramizol, an imidazole derivative, exhibits lipid-lowering and anti-atherogenic effects. In animals with acute hyperlipidemia induced by Triton WR-1339 cramizol reduced blood levels of cholesterol and triglycerides, and also the atherogenic index. Cramizol and the lipid-lowering drug fenofibrate demonstrated similar effectiveness as hypolipidemic agents. Cramizol also restored the expression of the Apoa1 gene in rats with experimentally induced hyperlipidemia to normal values. This may be a basis of its hypolipidemic and anti-atherogenic action.

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ACKNOWLEDGMENTS

The authors are very grateful to Dr N.N. Klyueva, a researcher at the Department of Biochemistry (IEM), for methodological assistance during this work.

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Authors and Affiliations

  1. Institute of Experimental Medicine (IEM), ul. Akad. Pavlova 12, 197376, St. Petersburg, Russia

    A. V. Lizunov, I. V. Okunevich, S. V. Orlov, A. A. Lebedev, E. R. Bychkov, L. B. Piotrovskiy & P. D. Shabanov

  2. Kirov Military Medical Academy, ul. Akad. Lebedeva 6, 194044, St. Petersburg, Russia

    E. R. Bychkov & P. D. Shabanov

  3. St. Petersburg State University, Universitetskaya nab. 7/9, 199034, St. Petersburg, Russia

    A. V. Lizunov & S. V. Orlov

Authors
  1. A. V. Lizunov
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  2. I. V. Okunevich
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  3. S. V. Orlov
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  4. A. A. Lebedev
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  5. E. R. Bychkov
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  6. L. B. Piotrovskiy
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  7. P. D. Shabanov
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Corresponding author

Correspondence to A. V. Lizunov.

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The experiments were performed in accordance with the principles of humanity (EU Directive No. 86/609 of the EU) and approved by the IEM Ethics Committee.

The authors declare that they have no conflict of interest.

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Translated by A. Medvedev

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Lizunov, A.V., Okunevich, I.V., Orlov, S.V. et al. The Effect of Сramizol on ApoA1 Gene Expression in Rats with Experimental Hyperlipidemia. Biochem. Moscow Suppl. Ser. B 14, 82–85 (2020). https://doi.org/10.1134/S1990750820010102

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  • DOI: https://doi.org/10.1134/S1990750820010102

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