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Representation Analysis of miRNA in Urine Microvesicles and Cell-Free Urine in Prostate Diseases

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Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Aims and scope Submit manuscript

Abstract

Urine of prostate cancer patients contains tumor-specific biopolymers, including protein- and microvesicles-associated miRNAs that can potentially be used as oncomarkers. Previously we have characterized urinary extracellular vesicles and demonstrated diagnostic potential of their miRNAs. In this study, we have performed a comparative analysis of 84 miRNA in paired samples of urine microvesicles and urine supernatant from healthy men, patients with benign prostate hyperplasia, and prostate cancer patients using miRCURY LNA miRNA qPCR Panels. In all groups of patients, miRNA subsets characterized by different distribution between the urinary fractions have been found. In this context, two groups of miRNAs have been identified, which are involved in several signaling pathways including those associated with prostate cancer development.

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences, pr. Akad. Lavrentieva 8, Novosibirsk, 630090, Russia

    I. A. Zaporozhchenko, O. E. Bryzgunova, E. A. Lekchnov, Yu. B. Yurchenko, E. Yu. Rykova & P. P. Laktionov

  2. Meshalkin Siberian Federal Biomedical Research Center, Novosibirsk, Russia

    I. A. Zaporozhchenko, O. E. Bryzgunova, E. A. Lekchnov, S. V. Yarmoschuk, O. A. Pashkovskaya, E. Yu. Rykova, A. A. Zheravin & P. P. Laktionov

  3. Novosibirsk State University, Novosibirsk, Russia

    I. D. Osipov

  4. Siberian District Medical Center, Novosibirsk, Russia

    M. M. Zaripov

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  1. I. A. Zaporozhchenko
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  2. O. E. Bryzgunova
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  6. Yu. B. Yurchenko
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Corresponding author

Correspondence to I. A. Zaporozhchenko.

Additional information

Original Russian Text © I.A. Zaporozhchenko, O.E. Bryzgunova, E.A. Lekchnov, I.D. Osipov, M.M. Zaripov, Yu.B. Yurchenko, S.V. Yarmoschuk, O.A. Pashkovskaya, E.Yu. Rykova, A.A. Zheravin, P.P. Laktionov, 2018, published in Biomeditsinskaya Khimiya.

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Zaporozhchenko, I.A., Bryzgunova, O.E., Lekchnov, E.A. et al. Representation Analysis of miRNA in Urine Microvesicles and Cell-Free Urine in Prostate Diseases. Biochem. Moscow Suppl. Ser. B 12, 156–163 (2018). https://doi.org/10.1134/S1990750818020142

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  • DOI: https://doi.org/10.1134/S1990750818020142

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