Abstract
Homocysteine (HC) and a product of its spontaneous oxidation, homocysteic acid (HCA), are neurotoxic compounds; however, the mechanism of their neurotoxicity is unknown. We found that application of HCA to neurons results in an increase in the intracellular level of reactive oxygen species (ROS), activation of MAP kinase (MAPK) and, finally, in cell death. We found that HCA increases both cellular apoptosis and necrosis, whereas preliminary incubation of cells with carnosine protects cells from these types of cell death.
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Original Russian Text © E.S. Arzumanyan, M.S. Stepanova, 2010, published in Neirokhimiya, 2010, Vol. 27, No. 3, pp. 251–256.
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Arzumanyan, E.S., Stepanova, M.S. Mechanisms of homocysteic acid neurotoxicity. Neurochem. J. 4, 222–227 (2010). https://doi.org/10.1134/S1819712410030104
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DOI: https://doi.org/10.1134/S1819712410030104