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Reaction of 3-Amino-5H- and 3-Amino-5-sulfanyl-1,2,4-triazoles with 1,2,4-Triazine-5-carbonitriles

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Abstract

1,2,4-Triazines with an unsubstituted (1,2,4-triazol-3-yl)amine residue in the C5 position were synthesized by the solvent-free ipso-amination reaction between 1,2,4-triazine-5-carbonitriles and 3-amino-5H- or 3-amino-5-sulfanyl-1,2,4-triazoles. In the latter case, the reaction is accompanied by desulfurization of the 1,2,4-triazole fragment.

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Funding

The work was financially supported by the Council for Grants under the President of the Russian Federation (grant no. MD-167.2021.1.3), as well as through the State order (topic nos. AAAA-A19-119011790134-1 and AAAA-A19-119011790132-7).

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Authors and Affiliations

  1. Yeltsin Ural Federal University, 620002, Yekaterinburg, Russia

    A. P. Krinochkin, M. R. Guda, D. S. Kopchuk, Ya. K. Shtaitz, K. V. Savateev, E. N. Ulomsky, G. V. Zyryanov, V. L. Rusinov & O. N. Chupakhin

  2. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, 620219, Yekaterinburg, Russia

    A. P. Krinochkin, D. S. Kopchuk, K. V. Savateev, E. N. Ulomsky, G. V. Zyryanov, V. L. Rusinov & O. N. Chupakhin

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  1. A. P. Krinochkin
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  2. M. R. Guda
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  3. D. S. Kopchuk
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  4. Ya. K. Shtaitz
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  5. K. V. Savateev
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  6. E. N. Ulomsky
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  7. G. V. Zyryanov
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  8. V. L. Rusinov
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  9. O. N. Chupakhin
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Corresponding authors

Correspondence to D. S. Kopchuk or G. V. Zyryanov.

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The article is based on the materials of the report presented at the V International Conference “Modern Synthetic Methodologies for the Creation of Drugs and Functional Materials” (November 8–12, 2021, Yekaterinburg and Perm).

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Krinochkin, A.P., Guda, M.R., Kopchuk, D.S. et al. Reaction of 3-Amino-5H- and 3-Amino-5-sulfanyl-1,2,4-triazoles with 1,2,4-Triazine-5-carbonitriles. Russ J Org Chem 58, 188–191 (2022). https://doi.org/10.1134/S1070428022020051

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