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Solvent-Free Synthesis of Quinazolinone Derivatives Catalyzed by Wet Zinc Oxide Nanopowder under Air Atmosphere

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Abstract

Wet zinc oxide nanopowder was found to be a highly effective catalyst for the cyclization of o-aminobenzamide with aldehydes, followed by dehydrogenation under air atmosphere. The presence of moisture in the catalyst played a crucial role in the selective formation of quinazolin-4(3H)-ones under solvent-free conditions. The procedure is operationally simple, and it does not need toxic or volatile organic solvents and provides excellent yield of the products. Moreover, the catalyst was recycled and reused in three successive reactions without significant loss of activity.

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ACKNOWLEDGMENTS

The authors are thankful to Chairman, Agricultural Development Trust Baramati, Dist. Pune, for providing all necessary facilities required for this research work.

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Authors and Affiliations

  1. P.G. Department of Chemistry, Agricultural Development Trust’s, Sharadabai Pawar Mahila Arts, Commerce and Science College Shardanagar, 413115, Baramati, Maharashtra, India

    P. E. More, S. L. Khillare & N. S. Shinde

  2. Government Institute of Science, 440008, Nagpur, Maharashtra, India

    V. T. Kamble

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  1. P. E. More
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  2. S. L. Khillare
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  3. N. S. Shinde
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  4. V. T. Kamble
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More, P.E., Khillare, S.L., Shinde, N.S. et al. Solvent-Free Synthesis of Quinazolinone Derivatives Catalyzed by Wet Zinc Oxide Nanopowder under Air Atmosphere. Russ J Org Chem 58, 119–124 (2022). https://doi.org/10.1134/S1070428022010171

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  • DOI: https://doi.org/10.1134/S1070428022010171

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