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Efficient Synthesis of 4-Phenyl-4H-pyran Derivatives via a DIPEA-catalyzed One-Pot Three-Component Reaction

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Abstract

A novel one-pot approach has been developed for a high-yield synthesis of 4-phenyl-4H-pyran derivatives by the three-component condensation of dimethyl 3-oxopentanedioate or 3-oxo-3-arylpropanoic acid esters, aldehydes, with malononitrile in the presence of a DIPEA catalyst in ethanol at room temperature. The significant features of the present strategy include efficiency, high yield, inexpensive catalyst, mild reaction conditions, and simple purification procedure.

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Funding

This study was financially supported by the Shenyang Science & Technology project (project no. 18-013-0-03) and Natural Science Funds for Young Scholar of Liaoning University (project no. LDQN201436).

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Authors and Affiliations

  1. College of Pharmacy of Liaoning University, Key Laboratory of New Drug Research and Development of Liaoning Province, 66 Chongshan Road, Huanggu District, Shenyang, 110036, P.R. China

    Jun Li, Jie Li, Shi-yu Hu, Ye Chen & Ju Liu

Authors
  1. Jun Li
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  2. Jie Li
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  3. Shi-yu Hu
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  4. Ye Chen
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  5. Ju Liu
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Correspondence to Ye Chen or Ju Liu.

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Li, J., Li, J., Hu, Sy. et al. Efficient Synthesis of 4-Phenyl-4H-pyran Derivatives via a DIPEA-catalyzed One-Pot Three-Component Reaction. Russ J Org Chem 55, 1791–1799 (2019). https://doi.org/10.1134/S107042801911023X

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  • DOI: https://doi.org/10.1134/S107042801911023X

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