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Synthesis of Functionalized Partially Hydrogenated Quinolines by a Stork Reaction — Intramolecular Transamination — Alkylation Tandem Protocol

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Abstract

A Stork reaction — intramolecular transamination — alkylation tandem protocol was used to synthesize functionalized partially hydrogenated quinolines. The molecular and crystal structures of 5-(4-methoxyphenyl)-8,8-dimethyl-6-oxo-2,5,6,7,8,9-hexahydro-1H-thiazolo[3,2-a]quinoline-4-carbonitrile, 9-allyl-3-amino-7,7-dimethyl-5-oxo-4-phenyl-4,5,6,7,8,9-hexahydrothieno[2,3-b]quinoline-2-carbonitrile, and 3-amino-4-(2,5-dimethoxyphenyl)-N-phenyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide were studied by X-ray diffraction analysis.

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Authors and Affiliations

  1. Taras Shevchenko Lugansk National University, ul. Oboronnaya 2, Lugansk, 91011, Ukraine

    I. V. Dyachenko, I. N. Kalashnik & V. D. Dyachenko

  2. Kurchatov Institute National Research Center, ul. Akademika Kurchatova 1, Moscow, 123182, Russia

    P. V. Dorovatovskii & V. N. Khrustalev

  3. Peoples’ Friendship University of Russia (RUDN University), ul. Miklukho-Maklaya 6, Moscow, 117198, Russia

    V. N. Khrustalev

  4. Lomonosov Moscow State University, ul. Leninskie Gory 1, Stroenie 3, Moscow, 119991, Russia

    V. G. Nenaidento

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  1. I. V. Dyachenko
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  3. V. D. Dyachenko
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  4. P. V. Dorovatovskii
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Correspondence to I. V. Dyachenko, P. V. Dorovatovskii, V. N. Khrustalev or V. G. Nenaidento.

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Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 8, pp. 1273–1286.

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Dyachenko, I.V., Kalashnik, I.N., Dyachenko, V.D. et al. Synthesis of Functionalized Partially Hydrogenated Quinolines by a Stork Reaction — Intramolecular Transamination — Alkylation Tandem Protocol. Russ J Org Chem 55, 1177–1188 (2019). https://doi.org/10.1134/S1070428019080177

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