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A New Synthesis of Calcium N-(5-Hydroxynicotinoyl)-L-glutamate and Its X-ray Diffraction Structure

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Abstract

A new synthesis of N-(5-hydroxynicotinoyl)-L-glutamic acid via a 5-hydroxynicotinic acid imidazolide intermediate has been developed. Its calcium salt (Ampasse) has been synthesized and its structure was studied by X-ray diffraction analysis. The reaction conditions for all stages of the process have been optimized and a method for the purification of the substance has been improved.

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Authors and Affiliations

  1. Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991, Russia

    A. V. Kiselev & S. V. Stovbun

  2. BION, All-Russian Research Institute of Agricultural Radiology and Agroecology, Kievskoe shosse 109 km, Obninsk, Kaluzhskaya obl., 249032, Russia

    A. A. Machula, S. I. Efimov & E. B. Pashkova

Authors
  1. A. V. Kiselev
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  2. A. A. Machula
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  3. S. I. Efimov
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  4. E. B. Pashkova
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  5. S. V. Stovbun
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Corresponding authors

Correspondence to A. V. Kiselev or S. I. Efimov.

Additional information

Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 5, pp. 709–713.

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Kiselev, A.V., Machula, A.A., Efimov, S.I. et al. A New Synthesis of Calcium N-(5-Hydroxynicotinoyl)-L-glutamate and Its X-ray Diffraction Structure. Russ J Org Chem 55, 615–619 (2019). https://doi.org/10.1134/S1070428019050063

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  • DOI: https://doi.org/10.1134/S1070428019050063

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