Abstract
A general procedure has been proposed for the synthesis of thiazolo[3,2-a]quinazolin-5-one derivatives containing a sulfonamide group on C7 via intramolecular nucleophilic substitution of halogen in 2-halo-5-sulfamoyl-N-(1,3-thiazol-2-yl)benzamides. The effects of the degree of activation of the initial compound and halogen nature on the yield of the target products have been analyzed.
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Original Russian Text © R.M. Shlenev, S.I. Filimonov, A.V. Tarasov, A.S. Danilova, P.A. Agat’ev, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 1, pp. 76–82.
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Shlenev, R.M., Filimonov, S.I., Tarasov, A.V. et al. Synthesis of new sulfonamide derivatives of thiazolo[3,2-a]quinazolin-5-one. Russ J Org Chem 52, 69–75 (2016). https://doi.org/10.1134/S1070428016010139
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DOI: https://doi.org/10.1134/S1070428016010139