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Synthesis of 1-(1-aryl-1H-1,2,3-triazol-4-yl)-β-carboline derivatives

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Abstract

Reaction of 5-methyl-1-aryl-1H-1,2,3-triazole-4-carbocylic acid chlorides with tryptamine derivatives afforded substituted 1-aryl-N-[2-(1H-indol-3-yl)ethyl]-5-methyl-1H-1,2,3-triazole-4-carboxamides. At heating these compounds in toluene in the presence of POCl3 and P2O5 Bischler-Napieralski cyclization occurs giving 1-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-4,9-dihydro-3H-β-carbolines that can be transformed into β-carboline and tetrahydro-β-carboline derivatives.

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Correspondence to M. D. Obushak.

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Original English Text © N.T. Pohodylo, V.S. Matiichuk, M.D. Obushak, 2014, published in Zhurnal Organicheskoi Khimii, 2014, Vol. 50, No. 2, pp. 282–286.

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Pohodylo, N.T., Matiichuk, V.S. & Obushak, M.D. Synthesis of 1-(1-aryl-1H-1,2,3-triazol-4-yl)-β-carboline derivatives. Russ J Org Chem 50, 275–279 (2014). https://doi.org/10.1134/S1070428014020225

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  • DOI: https://doi.org/10.1134/S1070428014020225

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