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Transformations of 3-nitropyridin-4(1H)-one and 1-Methyl-3-nitropyridin-4(1H)-one in reaction with hydrazine

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Abstract

Hydrazinolysis of 3-nitropyridin-4(1H)-one and its N-methyl derivative leads to the formation of 1-(1H-pyrazol-3-yl)ethanone hydrazone whose structure was confirmed by independent synthesis from authentic 3-acetyl-1H-pyrazole and comparison of the IR and 1H NMR spectra. Oxidation of 1-(1H-pyrazol-3- yl)ethanone hydrazone with potassium permanganate gave 1H-pyrazole-3-carboxylic acid.

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Authors and Affiliations

  1. Litvinenko Institute of Physical Organic and Coal Chemistry, National Academy of Sciences of Ukraine, ul. R. Lyuksemburg 70, Donetsk, 83114, Ukraine

    N. N. Smolyar

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  1. N. N. Smolyar
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Correspondence to N. N. Smolyar.

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Original Russian Text © N.N. Smolyar, 2010, published in Zhurnal Organicheskoi Khimii, 2010, Vol. 46, No. 1, pp. 121–124.

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Smolyar, N.N. Transformations of 3-nitropyridin-4(1H)-one and 1-Methyl-3-nitropyridin-4(1H)-one in reaction with hydrazine. Russ J Org Chem 46, 122–125 (2010). https://doi.org/10.1134/S1070428010010124

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  • DOI: https://doi.org/10.1134/S1070428010010124

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