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Tetrazoles: L. Microwave-activated alkylation of 5-aryltetrazoles and 1-substituted tetrazole-5-thiones with 1,3-dibromo-2,2-bis(bromomethyl)propane

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Abstract

Alkylation of 5-aryltetrazoles and 1-substituted tetrazole-5-thiones with 1,3-dibromo-2,2-bis(bromomethyl)propane in dimethylformamide in the presence of sodium hydroxide leads to the formation of tetrakis(5-aryltetrazol-2-ylmethyl)methanes and tetrakis(1-R-tetrazol-5-ylsulfanylmethyl)methanes, respectively. Microwave activation considerably shortens the reaction time and increases the yield.

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Authors and Affiliations

  1. St. Petersburg State Institute of Technology, Moskovskii pr. 26, St. Petersburg, 190013, Russia

    M. V. Zatsepina, T. V. Artamonova & G. I. Koldobskii

  2. Faculty of Pharmacy, Charles University in Prague, Heyrovskeho 1203, Hradec Kralove, 50005, Czech Republic

    A. Hrabalek

Authors
  1. M. V. Zatsepina
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  2. A. Hrabalek
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  3. T. V. Artamonova
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  4. G. I. Koldobskii
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Additional information

Original Russian Text © M.V. Zatsepina, A. Hrabalek, T.V. Artamonova, G.I. Koldobski, 2006, published in Zhurnal Organicheskoi Khimii, 2006, Vol. 42, No. 12, pp. 1844–1847.

For communication XLIX, see [1].

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Zatsepina, M.V., Hrabalek, A., Artamonova, T.V. et al. Tetrazoles: L. Microwave-activated alkylation of 5-aryltetrazoles and 1-substituted tetrazole-5-thiones with 1,3-dibromo-2,2-bis(bromomethyl)propane. Russ J Org Chem 42, 1834–1837 (2006). https://doi.org/10.1134/S1070428006120128

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  • DOI: https://doi.org/10.1134/S1070428006120128

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