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Synthesis of 5-[4-(Arylsulfanyl)phenyl]-2,2′-bipyridines Using Aryne Intermediates

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Abstract

A convenient method for the preparation of 5-aryl-2,2′-bipyridines with para-arylsulfanyl group in an aromatic substituent was proposed. The synthesis was performed using in situ generated aryne intermediates without the use of complex experimental procedures and expensive reagents/catalysts. The structure of one product was confirmed by XRD data. This approach is a new variant for the preparation of 5-aryl-2,2’-bipyridines with an extended conjugation system.

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Funding

This work was supported by the Russian Science Foundation (project no. 22-73-00292) using the equipment of the Center for the Collective Use “Spectroscopy and Analysis of Organic Compounds.”

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Authors and Affiliations

  1. Ural Federal University, 620002, Yekaterinburg, Russia

    E. S. Starnovskaya, A. P. Krinochkin, S. S. Rybakova, A. L. Muzyka, P. A. Slepukhin, D. S. Kopchuk, G. V. Zyryanov & O. N. Chupakhin

  2. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 620219, Yekaterinburg, Russia

    E. S. Starnovskaya, A. P. Krinochkin, P. A. Slepukhin, D. S. Kopchuk, G. V. Zyryanov & O. N. Chupakhin

Authors
  1. E. S. Starnovskaya
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  2. A. P. Krinochkin
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  3. S. S. Rybakova
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  4. A. L. Muzyka
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  5. P. A. Slepukhin
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  6. D. S. Kopchuk
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  7. G. V. Zyryanov
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  8. O. N. Chupakhin
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Correspondence to A. P. Krinochkin.

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Starnovskaya, E.S., Krinochkin, A.P., Rybakova, S.S. et al. Synthesis of 5-[4-(Arylsulfanyl)phenyl]-2,2′-bipyridines Using Aryne Intermediates. Russ J Gen Chem 93, 1680–1686 (2023). https://doi.org/10.1134/S107036322307006X

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