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Study on the Preparation Technology of Omeprazole Vesicles

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Abstract

Herein a study on the process of converting omeprazole into omeprazole vesicles by a film dispersion method is presented. Using encapsulation efficiency as an index, the formulation and technology of omeprazole vesicles are optimized by a single factor experiment and a central composite design-response surface method. The optimized formulation and technology are as follows: the ratio of Tween-80 to cholesterol is 3 : 1, the hydration time is 65 min, the hydration temperature is 30°C, and hydration solvent pH is 11. Under such conditions, the average particle diameter of the obtained the omeprazole vesicles is 70 nm, and the encapsulation efficiency is 92.40%, which is close to the theoretical value of 93.43%. Transmission electron microscope (TEM) characterization reveals that the omeprazole vesicles are of regular spherical shape, and IR and TG characterization demonstrate that omeprazole has been encapsulated by the vesicles. The release time of pure omeprazole drug in simulated human intestinal fluid (pH = 6.8) is about 70 min, and the release time of omeprazole vesicles is ca 75 min, with a release rate of 33.19%.

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Authors and Affiliations

  1. Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, 550025, Guiyang, China

    Wenjing Deng, Zhimei Wang, Yuehuan Zhang, Qing Chen & Xin Xiao

  2. Department of Chemistry, University of Hull, HU6 7RX, Hull, UK

    Carl Redshaw

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  1. Wenjing Deng
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  2. Zhimei Wang
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  3. Yuehuan Zhang
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  4. Qing Chen
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  5. Xin Xiao
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Correspondence to Qing Chen or Carl Redshaw.

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Deng, W., Wang, Z., Zhang, Y. et al. Study on the Preparation Technology of Omeprazole Vesicles. Russ J Gen Chem 91, 2311–2319 (2021). https://doi.org/10.1134/S1070363221110190

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