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N,N-Di(prop-2-yn-1-yl)adamantan-1-amines in 1,3-Dipolar Cycloaddition Reactions with Azide-Containing Pharmacophores

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Abstract

A synthetic approach to combining pharmacophore ligands with an aminoadamantyl-containing spacer based on a copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition of N,N-di(prop-2-yne-1-yl)adamantan-1-amines and azido-containing carbazole, tetrahydrocarbazole, phenothiazine and adamantan-2-amine derivatives was proposed.

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Funding

This work was financially supported by the Russian Science Foundation (project no. 14-23-00160-P, synthesis of compounds 9–12) and the Ministry of Education and Science in the framework of the governmental task for 2018 (topic no. 0090-2017-0023).

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Authors and Affiliations

  1. Institute of Physiologically Active Substances of the Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, 142432, Russia

    V. B. Sokolov & A. Yu. Aksinenko

Authors
  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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Corresponding author

Correspondence to A. Yu. Aksinenko.

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Conflict of Interest

No conflict of interest was declared by the authors.

Russian Text © The Author(s), 2019, published in Zhurnal Obshchei Khimii, 2019, Vol. 89, No. 8, pp. 1300–1304.

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Sokolov, V.B., Aksinenko, A.Y. N,N-Di(prop-2-yn-1-yl)adamantan-1-amines in 1,3-Dipolar Cycloaddition Reactions with Azide-Containing Pharmacophores. Russ J Gen Chem 89, 1724–1727 (2019). https://doi.org/10.1134/S1070363219080280

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  • DOI: https://doi.org/10.1134/S1070363219080280

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