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Synthesis and antibacterial activity of novel 4-{4-(methylamino)thieno[3,2-d]pyrimidin-2-yl}-benzohydrazide derivatives

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Abstract

A series of novel 4-{4-(methylamino)thieno[3,2-d]pyrimidin-2-yl}benzohydrazide derivatives were synthesized and evaluated for their antibacterial activity. Most of the compounds demonstrated high activity towards Escherichia coli, Pseudomonas, Staphylococcus aureus, and Bacillus. Structures of all synthesized compounds were confirmed by spectral analysis.

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References

  1. Chimenti, F., Maccioni, E., Secci, D., Bolasco, A., Chimenti, P., Granese, A., Befani, O., Turini, P., Alcaro, S., Ortuso, F., Cardia, M.C., and Distinto, S., J. Med. Chem., 2007, vol. 50, p. 707. doi 10.1021/jm060869d

    Article  CAS  Google Scholar 

  2. Rollas, S. and Kucukguzel, S.G., Molecules, 2007, vol. 12, p. 1910. doi 10.3390/12081910

    Article  CAS  Google Scholar 

  3. Barbazan, P., Carballo, R., Covelo, B., Lodeiro C., Lima, J.C., and Vazquez-Lopez, E.M., Eur. J. Inorg. Chem., 2008, no. 17, p. 2713. doi 10.1002/ejic.200701199

    Article  Google Scholar 

  4. Durgun, B., Capan, G., Ergenc, N., and Rollas, S., Pharmazie, 1993, vol. 48, no. 12, p. 942

    CAS  Google Scholar 

  5. Olayinka, O.A., Craig, A.O., Obinna, C.N., and David, A.A., Bioorg. Med. Chem., 2010, vol. 18, p. 214.

    Article  Google Scholar 

  6. Rollas, S., Gulerman, N., and Edeniz, H., Farmaco IL., Int. J. Org. Chem., 2002, vol. 57, p. 171.

    CAS  Google Scholar 

  7. Cukurovali, A., Yilmaz, B., Gur, S., and Kazaz, C., Eur. J. Med. Chem., 2006, vol. 41, p. 201. doi org/10.1016/j.ejmech.2005.01.013

    Article  CAS  Google Scholar 

  8. Mamolo, M.G., Falagiani, V., Zampieri, D., Vio, U., Banfi, E., and Scialino, G., Farmaco IL, J. Med. Chem. Drug Discover., 2003, vol. 58, p. 631.

    CAS  Google Scholar 

  9. Capilla, J., Serena, C., Javier, F., Ortoneda, T., and Guarro, J., Antimicrob. Agents Chemother., 2003, vol. 47, p. 3976.

    Article  CAS  Google Scholar 

  10. Todeschini, A.R., Miranda, A.L., Silva, C.M., Parrini, S.C., and Barreiro, E.J., Eur. J. Med. Chem., 1998, vol. 33, p. 189. doi org/10.1016/S0223-5234(98)80008-1

    Article  CAS  Google Scholar 

  11. Lima, P.C., Lima, L.M., Silva, K.C., Leda, P.H., Miranda, A.L.P., Fraga, C.A.M., and Barreiro. E.J., Eur. J. Med. Chem., 2000, vol. 35, p. 187. doi org/10.1016/S0223-5234(98)80008-1

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Sreenidhi Institute of Science and Technology (Autonomous), Ghatkesar, Hyderabad, Telangana, 501301, India

    T. Giri, G. Sailaja & E. Laxminarayana

  2. Jawaharlal Nehru Technological University Hyderabad, Hyderabad, Telangana, 500085, India

    M. Thirumala Chary

  3. Jawaharlal Nehru Technological University Kakinada, Kakinada, Telangana, 533003, India

    M. Ramesh

Authors
  1. T. Giri
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  2. G. Sailaja
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  3. E. Laxminarayana
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  4. M. Thirumala Chary
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  5. M. Ramesh
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Corresponding author

Correspondence to E. Laxminarayana.

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The text was submitted by the authors in English.

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Giri, T., Sailaja, G., Laxminarayana, E. et al. Synthesis and antibacterial activity of novel 4-{4-(methylamino)thieno[3,2-d]pyrimidin-2-yl}-benzohydrazide derivatives. Russ J Gen Chem 87, 1275–1280 (2017). https://doi.org/10.1134/S1070363217060238

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  • DOI: https://doi.org/10.1134/S1070363217060238

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