Skip to main content
SpringerLink
Log in

Quantitative structure-property relationship: XXVI. Toxicity of aliphatic carboxylic acids

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

The previously suggested quantitative structure-property relationship was used for predicting properties of aliphatic carboxylic acids. The boiling points, octanol-water partition factors (logP), and toxicities [log(1/IGC50)] were calculated for a series of monocarboxylic, dicarboxylic, and unsaturated monocarboxylic acids. The calculated values are well consistent with the experimental data.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Golovanov, I.B. and Zhenodarova, S.M., Zh. Obshch. Khim., 2005, vol. 75, no. 12, p. 1994.

    Google Scholar 

  2. Seward, J.R. and Schultz, T.W., SAR-QSAR Environ. Res., 1999, vol. 10, p. 557.

    CAS  Google Scholar 

  3. Maguna, F.P., Nuñez, M.B., Okulik, N.B., and Castro, E.A., Zh. Obshch. Khim., 2003, vol. 73, no. 11, p. 1893.

    Google Scholar 

  4. Golovanov, I.B. and Zhenodarova, S.M., Zh. Obshch. Khim., 2003, vol. 73, no. 1, p. 90.

    Google Scholar 

  5. Cronin, M.T. and Sahulty, T.W., Chemosphere, 1996, vol. 32, no. 6, p. 1453.

    CAS  Google Scholar 

  6. Selasste, C.D., Shusterman, A.J., Kapur, S., Verma, R.P., Zhang, L., and Hansch, C., J. Chem. Soc., Perkin Trans. 2, 1999, p. 2729.

  7. Golovanov, I.B., Zhenodarova, S.M., Ivanitskii, G.R., and Sedel’nikova, E.A., Dokl. Ross. Akad. Nauk, 2002, vol. 382, no. 5, p. 695.

    Google Scholar 

  8. Hansch, C., Leo, A., and Hockman, D., Exploring QSAR, Washington: Am. Chem. Soc., 1995, vol. 2.

    Google Scholar 

  9. Golovanov, I.B. and Zhenodarova, S.M., Zh. Obshch. Khim., 2004, vol. 74, no. 6, p. 900.

    Google Scholar 

  10. Golovanov, I.B. and Zhenodarova, S.M., Zh. Obshch. Khim., 2003, vol. 73, no. 3, p. 400.

    Google Scholar 

  11. Svoistva organicheskikh soedinenii (Properties of Organic Compounds), Potekhin, A.A., Ed., Leningrad: Khimiya, 1984.

    Google Scholar 

  12. Golovanov, I.B. and Zhenodarova, S.M., Zh. Obshch. Khim., 2005, vol. 75, no. 1, p. 82.

    Google Scholar 

  13. Newman, M.S., Steric Effects in Organic Chemistry, New York: Wiley, 1956. Translated under the title Prostranstvennye effekty v organicheskoi khimii, Moscow: Inostrannaya Literatura, 1960, p. 212.

    Google Scholar 

  14. Golovanov, I.B. and Tsygankova, I.G., Zh. Obshch. Khim., 2000, vol. 70, no. 2, p. 223.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia

    I. B. Golovanov & S. M. Zhenodarova

Authors
  1. I. B. Golovanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. M. Zhenodarova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Original Russian Text © I.B. Golovanov, S.M. Zhenodarova, 2006, published in Zhurnal Obshchei Khimii, 2006, Vol. 76, No. 1, pp. 44–48.

For communication XXV, see [1].

Rights and permissions

Reprints and permissions

About this article

Cite this article

Golovanov, I.B., Zhenodarova, S.M. Quantitative structure-property relationship: XXVI. Toxicity of aliphatic carboxylic acids. Russ J Gen Chem 76, 40–44 (2006). https://doi.org/10.1134/S1070363206010099

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363206010099

Keywords

Search

Navigation