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Synthesis and Antimicrobial Activity of New Dihydropyrazolo[1,5-a]pyrimidine Derivatives

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Abstract

Objective: To synthesize new dihydropyrazolo[1,5-a]pyrimidine derivatives and screen for the antibacterial and antifungal screening. Methods: We have synthesized a new series of 7-(1,3-diphenyl-1-H-pyrazol4-yl)-2-(methylthio)-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3,6-dicarbonitrile compounds and screened compounds for antibacterial and antifungal activity. Gram-positive (Bacillus megaterium, Micrococcus spp.) and Gram-negative bacteria were tested for antibacterial activity (E.coli, S. typhi). Antifungal activity was tested on Ganoderma spp., A. niger, A. flavus, and Penicillium spp. Results: Some compounds have shown significant antimicrobial activity. Discussion: As per the results the compound possesses good biological activity due to presence of core pyrazolo[1,5-a]pyrimidine moiety. Conclusions: The synthesis of new 7-(1,3-diphenyl-1-Hpyrazol-4-yl)-2-(methylthio)-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3,6-dicarbonitrile compounds was successfully completed and characterized by relevant techniques. Compounds are screened for the biological activities with moderate to good results. The MIC of the synthesized compound is compared to marketed available standard drugs.

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Scheme 2.

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DATA AVAILABILITY

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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ACKNOWLEDGMENTS

The authors thank the Department of Chemistry, Government Science College, Fort-Songadh, India, Department of Chemistry, D.K..V Arts and Science College, Jamnagar, India, and Department of Chemistry, School of Science, R.K. University, Rajkot, India. for providing laboratory and other necessary facilities.

None of the authors are working on any project.

Funding

This work was supported by regular institutional funding, and no additional grants were obtained.

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Authors and Affiliations

  1. Chemistry Department, Government Science College, Vadnagar, 384355, Gujarat, India

    K. A. Joshi & H. B. Pandya

  2. Chemistry Department, D.K.V. Arts and Science College, Jamnagar, 361008, Gujarat, India

    A. K. Mahida

  3. Department of Microbiology, School of Science, R.K. University, 360020, Rajkot, India

    I. J. Modasiya

  4. Department of Chemistry, School of Science, R.K. University, 360020, Rajkot, India

    G. G. Dubal

Authors
  1. K. A. Joshi
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  2. H. B. Pandya
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  3. A. K. Mahida
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  4. I. J. Modasiya
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  5. G. G. Dubal
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Contributions

The authors KAJ, HBP, and AKM participated in the synthesis, purification, and analysis of the data of the synthesized compound; the author and author IJM carried out the anti-microbial evaluation and prepared analysis of the activity data while author GGD organized data and written manuscript and handled all over the organization of work and guided for the target work to other.

Corresponding author

Correspondence to G. G. Dubal.

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This article does not contain any studies involving patients or animals as test objects.

Informed consent was not required for this article. No conflict of interest was declared by the authors.

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Joshi, K.A., Pandya, H.B., Mahida, A.K. et al. Synthesis and Antimicrobial Activity of New Dihydropyrazolo[1,5-a]pyrimidine Derivatives. Russ J Bioorg Chem 50, 304–312 (2024). https://doi.org/10.1134/S1068162024020134

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