Skip to main content
Log in

Herbal Drugs in Cancer Treatment

  • REVIEW
  • Published:
Russian Journal of Bioorganic Chemistry Aims and scope Submit manuscript

Abstract

For centuries, herbal drugs have been used in various civilizations across the globe. India has its own ancient awareness on herbal drugs that people used without knowing their medicinal value or why they consume them. The changing lifestyle that individuals nowadays are leading and the increasing amount of synthetic chemicals and pollutants that they are being exposed to, many diseases and disorders are becoming more prevalent in modern societies. Cancer is one of these illnesses that causes morbidity and mortality among humankind, contributing to 9.6 million deaths annually. Even drug-resistant types of cancer have begun to increase, requiring a search for innovative and effective remedies. Herbal drugs may provide that potential cure. Plants like Boerhavia diffusa (Punarnava), Curcuma longa (Turmeric), Tinospora cordifolia, Simarouba glauca and many others are known to possess anti-cancerous properties. Molecular isolation and chemical modification of active compounds may be the key to finding the cure everyone is looking for. This paper examines herbal drugs that are being studied extensively, due to their anticancer properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.
Fig. 7.
Fig. 8.
Fig. 9.
Fig. 10.
Fig. 11.

Similar content being viewed by others

REFERENCES

  1. Bailar, J.C., and Gornik, H.L., N. Engl. J. Med., 1997, vol. 336, no. 22, pp. 1569–1574. https://doi.org/10.1056/NEJM199705293362206

    Article  Google Scholar 

  2. Giordano, A. and Tommonaro, G., Nutrients, 2019, vol. 11, no. 10, p. 2376. https://doi.org/10.3390/nu11102376

    Article  CAS  Google Scholar 

  3. Weinberg, R.A., Sci. American, 1996, vol. 275, no. 3, pp. 62–70. https://www.jstor.org/stable/24993349.

    Article  CAS  Google Scholar 

  4. Deorukhkar, A, Krishnan, S., Sethi, G., and Aggarwal, B.B., Exp. Opin. Investigat. Drugs, 2007, vol. 16, no. 11, pp. 1753–1773. https://doi.org/10.1517/13543784.16.11.1753

    Article  CAS  Google Scholar 

  5. Safarzadeh, H., Shotorbani, S.S., and Baradaran, B., Adv. Pharm. Bull., 2014, vol. 4, no. l, p. 421. https://doi.org/10.5681/apb.2014.062

    Article  Google Scholar 

  6. Tsuda, H., Ohshima, Y., Nomoto, H., Fujita, K., Matsuda, E., Iigo, M., Takasuka, N., and Moore, M.A., Drug Metab. Pharmacokinet., 2004, vol. 19, no. 4, pp. 245–263. https://doi.org/10.2133/dmpk.19.245

    Article  CAS  Google Scholar 

  7. Tan, C., Xu, X., Shang, Y., Fu, X., Xia, G., and Yang, H., Pharm. Mag., 2014, vol. 10, no. 40, pp. 536–540. https://doi.org/10.4103/0973-1296.141799

    Article  CAS  Google Scholar 

  8. Chen, C., Hong, X., Weng, J., Zhu, H., and Liu, Q., Am. J. Plant Sci., 2015, vol. 6, pp. 3075–3081. https://doi.org/10.4236/ajps.2015.619300

    Article  CAS  Google Scholar 

  9. Radhakrishnan, S., Reddivari, L., Sclafani, R., Das, U.N., and Vanamala, J., Front. Biosci. (Elite Ed.), 2011, vol. 3, pp. 1509–1523. https://doi.org/https://doi.org/10.2741/352

  10. Shlomo, W., Walfisch, Y., Kirilov, E., Linde, N., Mnitentag, H., Agbaria, R., Sharoni, Y., and Levy, L., Eur. J. Cancer Prevention, 2007, pp. 298–303. https://doi.org/10.1097/01.cej.0000236251.09232.7b

  11. Zaini, G., Brandt, K., Clench, M.R., and Le Maitre, C.L., Anti-Cancer Agents Med. Chem., 2012 vol. 12, no. 6, pp. 640–652. https://doi.org/10.2174/187152012800617704

    Article  CAS  Google Scholar 

  12. Perabo, F.G.E., Von Löw E.C., Ellinger, J., Von Rücker, A., Müller, S.C., and Bastian, P.J., Prostate Cancer Prostatic Dis., 2008, vol. 11, no. 1, pp. 6–12. https://doi.org/10.1038/sj.pcan.4501000

    Article  CAS  Google Scholar 

  13. Rathore, K. and Wang, H.C.R., Mol. Carcinogen., 2012, vol. 51, no. 3, pp. 280–289. https://doi.org/10.1002/mc.20844

    Article  CAS  Google Scholar 

  14. Bell, C. and Hawthorne, S., J. Pharm. Pharmacol., 2008, vol. 60, no. 2, pp. 139–144. https://doi.org/10.1211/jpp.60.2.0001

    Article  CAS  Google Scholar 

  15. George, V.C., Vijesh, V.V., Amararathna, D.I.M., Lakshmi, C.A., Anbarasu, K., Kumar, D.R.N., Ethiraj, K.R., Kumar, R.A., and Rupasinghe, H.P.V., Curr. Med. Chem., 2016, vol. 23, no. 32, pp. 3697–3716. https://doi.org/10.2174/0929867323666160627110342

    Article  CAS  Google Scholar 

  16. Gonçalves, C., Pereira, P., Schellenberg, P., Coutinho, P.J., and Gama, F.M., Mol. Nutrit. Food Res., 2008, vol. 52, pp. S103–S127. https://doi.org/10.4236/jbnb.2012.32024

    Article  CAS  Google Scholar 

  17. Panda, A.K., Chakraborty, D., Sarkar, I., Khan, I., and Sa, G., J. Exp. Pharm., 2017, vol. 9, pp. 31–45. https://doi.org/10.2147/JEP.S70568

    Article  CAS  Google Scholar 

  18. Mehta, K., Pantazis, P., McQueen, T., and Aggarwal, B.B., Anti-Cancer Drugs, 1997, vol. 8, no. 5, pp. 470–481. https://doi.org/10.1097/00001813-199706000-00010

    Article  CAS  Google Scholar 

  19. Vallianou, N.G., Evangelopoulos, A., Schizas, N., and Kazazis, C., Anticancer Res., 2015, vol. 35, no. 2, pp. 645–651.

    CAS  Google Scholar 

  20. Mosley, C.A., Liotta, D.C., and Snyder, J.P., Mol. Targets Ther. Curcumin Health Dis., 2007, pp. 77–103. https://doi.org/10.1007/978-0-387-46401-5_2

  21. Safarzadeh, E., Shotorbani, S.S., and Baradaran, B., Adv. Pharm. Bull., 2014, vol. 4, no. 1, pp. 421–427. https://doi.org/10.5681/apb.2014.062

    Article  Google Scholar 

  22. Menon, L.G., Kuttan, R., and Kuttan, G., Cancer Lett., 1995, vol. 95, pp. 221–225. https://doi.org/10.1016/0304-3835(95)03887-3

    Article  CAS  Google Scholar 

  23. Busquets., Carbó, S.N., Almendro, V., Quiles, M.T., Soriano, F.J.L., and Argilés, J.M., Cancer Lett., 2001, vol. 167, no. 1, pp. 33–38. https://doi.org/10.1016/S0304-3835(01)00456-6

  24. Kuo, M.L., Huang, T.S., and Lin, J.K., Biochim. Biophys. Acta, 1996, vol. 1317, pp. 95–100. https://doi.org/10.1016/S0925-4439(96)00032-4

    Article  CAS  Google Scholar 

  25. Kusanur, R. and Kulkarni. M., Asian J. Chem., 2014, vol. 26, no. 4, pp. 1077–1080. https://doi.org/10.14233/ajchem.2014.15865

    Article  CAS  Google Scholar 

  26. Mishra, S., Aeri, V., Kumar Gaur, P., and Jachak, S.M., BioMed. Res. Int., 2014, vol. 2014, p. 19. https://doi.org/10.1155/2014/808302

    Article  Google Scholar 

  27. Rajesh, K., Gautam, S., Singh, K.D., Kumar, P., Nilufar, H., Vibha, Y., Kumar, R., Diwakar, R.P., Rishikant, and Kumar, S.B., Int. J. Chem. Studies, 2018, vol. SP4, pp. 72–80.

    Google Scholar 

  28. Bharali, R., Azad, M.H.R., and Tabassum, J., Indian J. Physiol. Pharmacol., 2003, vol. 47, no. 4, pp. 459–464.

    Google Scholar 

  29. Satyavati, G.V., Raina, M.K., and Sharma M., Med. Plants India, 1976.

    Google Scholar 

  30. Sinan, K.I., Akpulat, U., Afaf A., Aldahish., Altunoglu, Y.C., Baloğlu, M.C., Zheleva-Dimitrova, D., Gevrenova, R., et al., Antioxidants, 2021, vol. 10, no. 12, p. 2003. https://doi.org/10.3390/antiox10122003

    Article  CAS  Google Scholar 

  31. Srivastava, R., Saluja, D., Dwarakanath, B.S., and Chopra, M., Evid.-Based Complement. Altern. Med., vol. 2011, pp. 1–13. https://doi.org/10.1093/ecam/nep223

  32. Tungpradit, R., Sinchaikul, S., Phutrakul, S., Wongkham, W., and Chen, S.T., Chiang Mai J. Sci., 2010, vol. 37, no. 3, pp. 476–488.

    CAS  Google Scholar 

  33. Devprakash, K.K., Srinivasan, T., Gurav, S.S., and Singh, S., Asian J. Biochem. Pharm. Res., 2011, vol. 1, pp. 306–317.

    CAS  Google Scholar 

  34. Goel, H.C., Prasad, J., Singh, S., et al., J. Radiat. Res., 2004, vol. 45, pp. 61–68. https://doi.org/10.1269/jrr.45.61

    Article  Google Scholar 

  35. Patel, A., Bigoniya, P., Singh, C.S., and Patel, N.H., Indian J. Pharm., 2013, vol. 45, no. 3, pp. 237–243. https://doi.org/10.4103/0253-7613.111919

    Article  Google Scholar 

  36. Jagetia, G.C., Nayak, V., and Vidyasagar, M.S., Cancer Lett., 1998, vol. 127, pp. 71–82. https://doi.org/10.1016/s0304-3835(98)00047-0

    Article  CAS  Google Scholar 

  37. Palmieri, A., Scapoli, L., Iapichino, A., Mercolini,L., Mandrone, M., Poli, F., Bruno A., Baserga, C., and Martinelli, M., Int. J. Immunopath. Pharm., 2019, vol. 33, pp. 1–10. https://doi.org/10.1177/2058738419855567

    Article  CAS  Google Scholar 

  38. Deepa, B., Babaji, H.V., Hosmani, J.V., Alamir, A.W.H., Mushtaq, S., Raj, A.T., and Patil, S., Appl. Sci., 2019, vol. 9, pp. 5147. https://doi.org/10.3390/app9235147

    Article  CAS  Google Scholar 

  39. Prajapati, C.K., Reddy, M.N., and Bhatt, M.H., Int. J. Botany Studies, 2018, vol. 3, no. 2, pp. 52–56.

    Google Scholar 

  40. Puranik, S.I., Ghagane, S.C., Nerli, R.B., Jalalpure, S.S., and Hiremath, M.B., Pharmacogn J., 2017, vol. 9, no. 6, pp. 906–912. https://doi.org/10.5530/pj.2017.6.142

    Article  CAS  Google Scholar 

  41. Jose, A., Chaitanya, M.V.N.L., Kannan, E., and Madhunapantula, S.V., Front Pharmacol., 2018, vol. 9, p. 127. https://doi.org/10.3389/fphar.2018.00127

    Article  CAS  Google Scholar 

  42. Ramasamy, S.P., Rajendran, A., Pallikondaperumal, M., Sundararajan, P., Husain, F.M., Khan, A., Hakeem, M.J., Alyousef, A.A., Albalawi, T., Alam, P., Ali, H.M., and Alqasim, A., Antibiotics, 2022, vol. 11, no. 1, p. 59. https://doi.org/10.3390/antibiotics11010059

    Article  CAS  Google Scholar 

  43. Biba, V., Kunjiraman, S., Rajam, S.S.N., and Anil, S., Asian Pac. J. Cancer Prev., 2021, vol. 22, no. 4, pp. 1305–1312. https://doi.org/10.31557/APJCP.2021.22.4.1305

    Article  Google Scholar 

  44. Jose, A., Chaitanya, M.V.N.L., Kannan, E., and Madhunapantula S.V., Front Pharmacol., 2018, vol. 9, p. 127. https://doi.org/10.3389/fphar.2018.00127

    Article  CAS  Google Scholar 

  45. Koiri, R.K. and Mehrotra, A., Anti-Cancer Agents Med. Chem., 2018, vol. 18, no. 13, pp. 1794–1795. https://doi.org/10.2174/187152061813190117122219

    Article  Google Scholar 

  46. Zhang, L., Zhang, L., Zhang, M., Pang, Y., Li, Z., Zhao, A., and Feng, J., Drug Deliv., 2015, vol. 22, no. 4, pp. 475–486. https://doi.org/10.3109/10717544.2013.861659

    Article  CAS  Google Scholar 

  47. Sah, A.K., Vyas, A.K., Suresh, P., and Gidwani, B., Artif. Cells Nanomed. Biotechnol., 2018, vol. 46, no. 4, pp. 650–657. https://doi.org/10.1080/21691401.2017.1373284

    Article  CAS  Google Scholar 

  48. Sachan, A.K. and Gupta, A., IJPSR, 2015, vol. 6, no. 3, pp. 961–970. https://doi.org/10.13040/IJPSR.0975-8232.6(3).961-70

    Article  Google Scholar 

  49. Ramawat, K.G., Herbal Drugs: Ethnomedicine to Modern Medicine, Berlin, Heidelberg: Springer, 2009. https://doi.org/10.1007/978-3-540-79116-4

Download references

ACKNOWLEDGMENTS

The authors are thankful to Rastreeya Sikshana Samithi Trust for constant support and encouragement.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Raviraj Kusanur.

Ethics declarations

COMPLIANCE WITH ETHICAL STANDARDS

The article does not involve any human/animal studies. As it is the review article it does not involve any experimental work.

Conflict of Interests

The authors declare that they have no conflicts of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Velur, G., Kusanur, R. Herbal Drugs in Cancer Treatment. Russ J Bioorg Chem 48, 1151–1158 (2022). https://doi.org/10.1134/S1068162022060267

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1068162022060267

Keywords:

Navigation