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Cyanine Dyes as Fluorogens for FAST and NanoFAST Proteins

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Abstract—

Seven new cyanine dyes were synthesized. These compounds, together with eleven described derivatives of the same class, have been probed as fluorogens for the FAST and nanoFAST proteins. The study of the increase in fluorescence intensity upon interaction with these proteins allowed us to identify structural elements suitable for the design of protein-labeling systems based on cyanine dye–fluorogen-activating protein pairs.

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Funding

The study was conducted with the financial support of the Russian Foundation for Basic Research within the framework of scientific project No. 20-34-70143.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia

    A. A. Khrulev, N. S. Baleeva, P. N. Kamzeeva, M. S. Baranov & A. V. Aralov

  2. Pirogov Russian National Research Medical University, 117997, Moscow, Russia

    N. S. Baleeva & M. S. Baranov

Authors
  1. A. A. Khrulev
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  2. N. S. Baleeva
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  3. P. N. Kamzeeva
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  4. M. S. Baranov
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  5. A. V. Aralov
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Corresponding author

Correspondence to A. V. Aralov.

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This article does not contain a description of any research involving humans and using animals as research subjects.

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The authors declare they have no conflicts of interest.

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Khrulev, A.A., Baleeva, N.S., Kamzeeva, P.N. et al. Cyanine Dyes as Fluorogens for FAST and NanoFAST Proteins. Russ J Bioorg Chem 48, 846–849 (2022). https://doi.org/10.1134/S1068162022040112

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  • DOI: https://doi.org/10.1134/S1068162022040112

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