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Design, Synthesis, and Biological Evaluation of a Novel Series of Pirfenidone Derivatives

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Abstract

In this study, a series of novel pirfenidone derivatives were designed and synthesized, and their activities against pulmonary fibrosis were evaluated. The structures of all the derivatives were characterized by 1H and 13C nuclear magnetic resonance and high-resolution mass spectrometry spectra. A preliminary investigation of their bioactivity demonstrated that all the target compounds exhibited different degrees of activity against pulmonary fibrosis and that the activities of most derivatives were markedly superior to that of pirfenidone.

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Funding

This study was supported by the Open Fund of Key Laboratory of Biotechnology and Bioresources Utilization (Dalian Minzu University), Ministry of Education (no. KF2021005), China.

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Authors and Affiliations

  1. College of Chemistry and Environment, Southwest Minzu University, Key Laboratory of Basic Chemistry, National Civil Commission, Chengdu, 610093, China

    Gengga Sangmao, Zhigang Yang & Hongjun Yang

  2. College of Chemistry, Sichuan University, Chengdu, 610000, China

    Yong Li & Shufan Yin

  3. Ningxia academy of metrology and quality inspection, Yinchuan, 750030, China

    Wei Wang

  4. Key Laboratory of Biotechnology and Bioresources Utilization (Dalian Minzu University), Ministry of Education, 116620, China

    Liming Jin

  5. College of Chemistry and Life Science, Chengdu Normal University, Chengdu, 610074, China

    Congdi Chen

Authors
  1. Gengga Sangmao
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  2. Yong Li
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  3. Wei Wang
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  4. Liming Jin
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  7. Congdi Chen
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  8. Hongjun Yang
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Correspondence to Hongjun Yang.

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This article does not contain any studies involving human participants performed by any of the authors and does not contain any studies involving animals performed by any of the author.

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Corresponding autor: e-mail: yanghj@swun.edu.cn.

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Gengga Sangmao, Li, Y., Wang, W. et al. Design, Synthesis, and Biological Evaluation of a Novel Series of Pirfenidone Derivatives. Russ J Bioorg Chem 48, 430–437 (2022). https://doi.org/10.1134/S1068162022020091

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