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Docking Simulation and Anti-Inflammatory Profile of Some Synthesized Heterodimer of Pyrazole

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Abstract

In the present studies, novel pyrazole derivatives have been synthesized linked through various linkers for the anti-inflammatory evaluation. The anti-inflammatory evaluation have been carried out by molecular docking and in vivo experimental models. The docking studies of these synthesized compounds have been performed with the active site of COX-2 compared to celecoxib and in vivo on carrageenan induced rat paw edema. Among all compounds (VIa and VIb) shown good anti-inflammatory activity.

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ACKNOWLEDGMENTS

Authors acknowledge UGC India for financial assistance of the work. Department of Chemistry, Banaras Hindu University, Varanasi, India is acknowledged for departmental facilities.

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  1. Department of Chemistry, Centre of Advance Studies, Institute of Science, Banaras Hindu University, 221005, Varanasi, India

    Pratima Yadav & Ashish Kumar Tewari

  2. Department of Chemistry, C.M.P. Degree College, 211002, Allahabad, India

    Ranjeet Kumar

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Pratima Yadav, Kumar, R. & Tewari, A.K. Docking Simulation and Anti-Inflammatory Profile of Some Synthesized Heterodimer of Pyrazole. Russ J Bioorg Chem 46, 1148–1155 (2020). https://doi.org/10.1134/S1068162020060370

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