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Antioxidant properties of conjugates of polyethylene glycols containing terpenophenolic fragments

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Abstract

A series of water-soluble conjugates has been synthesized from polyethylene glycols of various lengths and 4-bromomethyl-2,6-diisobornylphenol. The membrane protective and antioxidant activities of the synthesized products were evaluated on the model of the H2O2-induced hemolysis of erythrocytes. It was shown that the studied conjugates have a significant antioxidant activity, and a significant membrane protective effect was shown for the conjugates containing 0.2% and 0.8% of the 2,6-diisobornyl-4-methylenephenolic fragments.

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Abbreviations

PEG:

polyethylene glycol

LPO:

lipid peroxidation

TBA-RS:

products reacting with 2-thiobarbituric acid (TBA-reactive substances)

oxyHb:

oxyhemoglobin

metHb:

methemoglobin

ferrylHb:

ferrylhemoglobin

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Authors and Affiliations

  1. Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, ul. Pervomayskaya 48, Syktyvkar, 167982, Russia

    I. Yu. Chukicheva, M. A. Torlopov, E. V. Buravlev & A. V. Kuchin

  2. Institute of Biology, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, 167982, Russia

    O. G. Shevchenko

Authors
  1. I. Yu. Chukicheva
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  2. M. A. Torlopov
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  3. E. V. Buravlev
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  4. O. G. Shevchenko
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  5. A. V. Kuchin
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Corresponding author

Correspondence to E. V. Buravlev.

Additional information

Original Russian Text © I.Yu. Chukicheva, M.A. Torlopov, E.V. Buravlev, O.G. Shevchenko, A.V. Kuchin, 2014, published in Bioorganicheskaya Khimiya, 2014, Vol. 40, No. 1, pp. 85–91.

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Chukicheva, I.Y., Torlopov, M.A., Buravlev, E.V. et al. Antioxidant properties of conjugates of polyethylene glycols containing terpenophenolic fragments. Russ J Bioorg Chem 40, 76–81 (2014). https://doi.org/10.1134/S1068162014010026

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  • DOI: https://doi.org/10.1134/S1068162014010026

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