Skip to main content
SpringerLink
Log in

Comparative Bioevaluation of 99mTc Tricarbonyl and 99mTc-Sn(II) Lansoprazole as a Model for Peptic Ulcer Localization

  • Published:
Radiochemistry Aims and scope

Abstract

Two 99mTc cores, 99mTc tricarbonyl and 99mTc-Sn(II), are compared in labeling of Lansoprazole (Lans). The optimum conditions of Lansoprazole labeling with 99mTc in the presence of SnCl2·2H2O as a reducing agent are as follows: pH 8, 100 μg of SnCl2·2H2O, room temperature, 2 mg of lansoprazole, and 30 min; the maximum radiochemical yield was 98 ± 0.22%. The obtained 99mTc Lansoprazole complex was stable in serum for up to 16 h. The optimum conditions of Lansoprazole binding with the 99mTc tricarbonyl ([99mTc(CO)3(H2O)3]+) core are as follows: pH 8, 2 mg of Lansoprazole, 100°С, 30 min. The complex was stable in serum for up to 12 h. Biodistribution study of the first core on two different groups of mice (control group and ulcer-bearing group) showed comparatively high uptake in the ulcer group of mice, 77.8 ± 1.1% ID/g at 30 min post-injection (higher than for the control group); at 24 h, the uptake decreased to 17.9% ID/g. Similar results were obtained with 99mTc tricarbonyl Lansoprazole: 78.5% ID/g at 30 min post-injection and 24.6% at 24 h. Thus, both complexes are suitable as radiotracers for stomach ulcer imaging.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.

Similar content being viewed by others

REFERENCES

  1. Hirschowitz, B.I., Mohnen, J., and Shaw, S., Aliment. Pharmacol. Ther., 1996, vol. 10, no. 4, pp. 507–522.

    Article  CAS  Google Scholar 

  2. Singhal, K.S. and Rahman, S.Z., Indian Med. Gaz., 2001, vol. 135, no. 7, pp. 223–225.

    Google Scholar 

  3. Sterry, W. and Assaf, C., Erythroderma, Dermatology, Bolognia, J.L., Ed., St. Louis: Mosby, 2007.

    Google Scholar 

  4. Howard, J.M., Chremos, A.N., Collen, M.J., et al., Gastroenterology, 1985, vol. 88, no. 4, pp. 1026–1033.

    Article  CAS  Google Scholar 

  5. Meskanen, K., Ekelund, H., Laitinen, J., et al., J. Clin. Psychopharmacol., 2013, vol. 33, no. 4, pp. 472–478.

    Article  CAS  Google Scholar 

  6. Laura, P.J., Marshall, J.D., Heulitt, M.J., Wells, T.G., Letzig, B.A.L., and Kearns, G.L., J. Clin. Pharmacol., 1996, vol. 36, no. 1, pp. 48–54.

    Article  Google Scholar 

  7. Sanad, M.H., Saleh, G.M., and Marzook, F.A., J. Label. Compd. Radiopharm., 2017, vol. 60, pp. 600–607.

    Article  CAS  Google Scholar 

  8. Sanad, M.H., Salama, D.H., and Marzook, F.A., Radiochim. Acta, 2017, vol. 105, pp. 389–398.

    Article  CAS  Google Scholar 

  9. Sanad, M.H. and Challan, S.B., Radiochemistry, 2017, vol. 59, pp. 307–312.

    Article  CAS  Google Scholar 

  10. Sanad, M.H. and Ibrahim, I.T., Radiochemistry, 2013, vol. 55, pp. 341–345.

    Article  CAS  Google Scholar 

  11. Sanad, M.H., Radiochemistry, 2013, vol. 55, pp. 605–609

  12. Sanad, M.H. and Ibrahim, I.T., Radiochemistry, 2015, vol. 57, pp. 425–430.

    Article  CAS  Google Scholar 

  13. Sanad, M.H. and Talaat, H.M., Radiochemistry, 2017, vol. 59, pp. 396–401.

    Article  CAS  Google Scholar 

  14. Sanad, M.H., Rizvi, F.A., and Kumar, R.R., Radiochemistry, 2020, vol. 62, no. 1, pp. 119–124.

    Article  CAS  Google Scholar 

  15. Sanad, M.H., Safaa, B.C., Fawzy, A.M., Sayed, M.A.A., and Ebtisam, A.M., Radiochim. Acta, 2021, vol. 109, no. 2, pp. 109–117.

    Article  Google Scholar 

  16. Amin, A.M., Sanad, M.H., and Abd-Elhaliem, S.M., Radiochemistry, 2013, vol. 55, no. 6, pp. 624–628.

    Article  CAS  Google Scholar 

  17. Amin, A.M., Omar, M.M., Abd-Elhaliem, S.M., and Elshanawany, A.A., Radiochemistry, 2015, vol. 57, no. 2, pp. 182–186.

    Article  CAS  Google Scholar 

  18. Ibrahim, I.T., El-Tawoosy, M., and Talaat, H.M., International Scholarly Research Network, 2011, vol. 2011, pp. 1–6.

    Google Scholar 

  19. Unak, P., Lambrecht, F.Y., Biber, F.Z., Medine, I.E., and Teksoz, S., J. Radioanal. Nucl. Chem., 2004, vol. 261, no. 3, pp. 587–591.

    Article  CAS  Google Scholar 

  20. Bormans, G., Cleynhens, B., Adriaens, P., De Roo, M., and Verbruggen, A.M., J. Label. Comp. Radiopharm., 1993, vol. 33, p. 1065.

    Article  CAS  Google Scholar 

  21. Parker, D., Chem. Soc. Rev., 1990, vol. 19, p. 271.

    Article  CAS  Google Scholar 

  22. Vanbilloen, H.P., Bormans, G.M., De Roo, M.J., and Verbruggen, A.M., Nucl. Med. Biol., 1996, vol. 22, p. 325.

    Article  Google Scholar 

  23. Smerikarova, M., Bozhanov, S., and Maslarska, V., Indian J. Pharm. Sci., 2019, vol. 81, no. 6, pp. 1122–1127.

    Article  CAS  Google Scholar 

  24. Liu, H.R., Zhao, R.R., Jiao, X.Y., Wang, Y.Y., and Fu, M., J. Am. College Cardiol., 2002, vol. 39, no. 11, p. 1866.

    Article  CAS  Google Scholar 

  25. Byun, B.H., Kong, C.B., Lim, I., Choi, C.W., Song, W.S., Cho, W.H., Jeon, D.G., Koh, J.S., Lee, S.Y., and Lim, S.M., J. Nucl. Med., 2013, vol. 54, no. 7, p. 1053.

    Article  CAS  Google Scholar 

  26. Rhodes, B.A., Semin. Nucl. Med., 1974, vol. 4, pp. 281–293.

    Article  CAS  Google Scholar 

  27. Sanad, M.H., Eyssa, H.M., Gomaa, N.M., Marzook, F.A., and Bassem, S.A., Radiochimica Acta, 2021, vol. 109, pp. 711–718.

    Article  Google Scholar 

  28. Ibrahim, I.T. and Sanad, M.H., Radiochemistry, 2013, vol. 55, no. 3, pp. 336–339.

    Article  CAS  Google Scholar 

  29. Motaleb M. A., Adli A. S. A, El-Tawoosy M., Sanad M.H., and AbdAllah, M., J. Label Compd. Radiopharm., 2016, vol.59, pp. 157–163.

    Article  Google Scholar 

  30. Sanad, M.H., El-Bayoumy, A.S.A., and Alhussein, I. A., J. Radioanal. Nucl. Chem., 2017, vol. 311(1), pp. 1–14.

    Article  CAS  Google Scholar 

  31. Sanad, M.H. and Emad H.B., Radiochim. Acta, 2015, vol. 103(12), pp. 879–891.

    Article  CAS  Google Scholar 

  32. anad, M.H. and El-Tawoosy, M., Radioanalytical and Nuclear Chemistry, 2013, vol. 298, pp. 1105–1109.

    Article  Google Scholar 

  33. Sanad, M.H. and Amin, A.M., Radiochemistry, 2013, vol. 55, pp. 521–526.

    Article  CAS  Google Scholar 

  34. Ebtisam, A.M., Ahmed, S.E., and Fawzy, A.M., Journal of Radiation Research and Applied Sciences, 2019, vol. 12, pp. 304–310.

    Article  Google Scholar 

  35. Borai, E., Sanad, M.H., and Fouzy, A.S.M., Radiochemistry, 2016, vol. 58, no. 1, pp. 84–91.

    Article  CAS  Google Scholar 

  36. El-Kawy, O.A., Sanad, M.H., Marzook, F., Journal of Radioanalytical and Nuclear Chemistry, 2016, vol. 301(1), pp. 279–286.

    Article  Google Scholar 

  37. Sanad, M.H., Sakr,T.M., Walaa, H.A. A., Marzook,E.A., Journal of Radioanalytical and Nuclear Chemistry, 2017, vol. 314, pp. 1505–1515.

    Article  CAS  Google Scholar 

  38. Sanad, M.H., Farag, A.B., Salama, D.H., Journal of Labelled Compounds and Radiopharmaceuticals, 2018, vol. 61, pp. 501–508.

    Article  CAS  Google Scholar 

  39. Sanad, M.H., Journal of Analytical Science and Technology, 2014, vol. 5, p. 2.

    Article  Google Scholar 

  40. Sanad, M. H., Farouk, N., and Fouzy, A.S.M., Radiochim. Acta, 2017, vol. 105, pp. 729–737.

    Article  CAS  Google Scholar 

  41. Sanad, M.H. and Alhussein, A.I., Radiochim. Acta, 2018, vol. 106, pp. 229–238.

    Article  CAS  Google Scholar 

Download references

ACKNOWLEDGMENTS

I would like to extend my sincere thanks and gratitude to everyone who gave me even a small contribution to accomplish this fruitful work, starting with the authors participating in the this work, as well as my professors, colleagues and students. I would also like to thank my family who created the right conditions for me to do this work, my father, mother, wives, brothers as well as all my children: Mohammed, Menna, Abd-Allah, Hamdi, Mostafa and Maryam Sanad. In addition, this work was supported by STDF–National Research Centre under project number 41535.

Author information

Authors and Affiliations

  1. Labeled Compounds Department, Hot Laboratories Center, Egyptian Atomic Energy Authority, PB13759, Cairo, Egypt

    M. H. Sanad & F. A. Marzook

  2. Department of Physics and Engineering Mathematics, Faculty of Engineering, Ain Shams University, 11566, Cairo, Egypt

    M. H. Sanad

  3. College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, Gansu, China

    S. F. A. Rizvi

  4. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 12578, Giza, Egypt

    A. B. Farag

  5. Food Toxicology and Contaminants Department, National Research Centre, Dokki, PB12622, Cairo, Egypt

    A. S. M. Fouzy & Sabry A. Bassem

  6. Department of Pharmaceutical Chemistry, Dr. B. C. Roy College of Pharmacy and Allied Health Sciences, Durgapur, 713206, West Bengal, India

    Sudip Kumar Mandal

  7. Guru Nanak Institutions Technical Campus, Ibrahimpatnam, 501506, Hyderabad, India

    Soumya Stuti Patnaik

  8. Laboratory of Organometallics, Catalysis and Ordered Materials, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 430070, Wuhan, China

    Francis Verpoort 

  9. Ghent University, Global Campus Songdo, 119 Songdomunhwa-Ro, Yeonsu-Gu, 21985, Incheon, South Korea

    Francis Verpoort 

  10. Radiation Chemistry Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, PB13759, Cairo, Egypt

    H. M. Eyssa

Authors
  1. M. H. Sanad
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. M. Eyssa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. A. Marzook
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. B. Farag
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. F. A. Rizvi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sudip Kumar Mandal
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Soumya Stuti Patnaik
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A. S. M. Fouzy
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Sabry A. Bassem
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Francis Verpoort 
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to M. H. Sanad or S. F. A. Rizvi.

Ethics declarations

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sanad, M.H., Eyssa, H.M., Marzook, F.A. et al. Comparative Bioevaluation of 99mTc Tricarbonyl and 99mTc-Sn(II) Lansoprazole as a Model for Peptic Ulcer Localization. Radiochemistry 63, 642–650 (2021). https://doi.org/10.1134/S1066362221050131

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1066362221050131

Keywords:

Search

Navigation