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Modeling of the Complex of the N-Methyl–D-Aspartate (NMDA) Receptor with Lipids of the Postsynaptic Membrane

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Abstract

The model of the complex of the N-methyl–D-aspartate (NMDA) receptor with lipids of the postsynaptic membrane was obtained by molecular dynamics simulation. The time-dependent behavior of the components of the system is analyzed. The interactions of the NMDA receptor with lipids of the postsynaptic membrane are described. This complex can be used to study a system containing the NMDA receptor and lipids of the postsynaptic membrane at different concentrations.

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Funding

The study was financially supported by the Ministry of Science and Higher Education of the Russian Federation within the framework of the state assignment for the Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences (molecular dynamics simulations) and by the National Research Centre “Kurchatov Institute” (order no. 1363 on June 25, 2019; analysis of the results of computer modeling).

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Authors and Affiliations

  1. National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

    A. S. Komolov, D. E. Petrenko & V. I. Timofeev

  2. Shubnikov Institute of Crystallography of Federal Scientific Research Centre “Crystallography and Photonics”, Russian Academy of Sciences, 119333, Moscow, Russia

    V. I. Timofeev

Authors
  1. A. S. Komolov
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  2. D. E. Petrenko
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  3. V. I. Timofeev
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Corresponding author

Correspondence to A. S. Komolov.

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The authors declare no conflict of interest, financial or otherwise.

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Translated by T. Safonova

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Komolov, A.S., Petrenko, D.E. & Timofeev, V.I. Modeling of the Complex of the N-Methyl–D-Aspartate (NMDA) Receptor with Lipids of the Postsynaptic Membrane. Crystallogr. Rep. 66, 1010–1012 (2021). https://doi.org/10.1134/S1063774521060183

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  • DOI: https://doi.org/10.1134/S1063774521060183

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