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Mechanism of reaction of selenium elimination in diacetophenonyl selenide under the action of reduced glutathione

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Abstract

Products of reaction between the organoselenium xenobiotic, diacetophenonyl selenide (1,5-diphenyl-3-selenapenta-1,5-dione), and reduced glutathione at different molar ratios and pH values were studied by HPLC and TLC. Reaction intermediates, S-(acetophenylselenyl)glutathione and glutathione selenodisulfide, and reaction products, acetophenone and hydroselenide anion, were detected. The reaction scheme proposed earlier was confirmed.

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Authors and Affiliations

  1. Penza State University of Architecture and Construction, Penza, 440028, Russia

    P. A. Poluboyarinov & P. P. Leshchenko

  2. Penza State University, Penza, 440026, Russia

    I. Ya. Moiseeva

  3. National Research Nuclear University MEPhI, Obninsk, 249040, Russia

    S. G. Kolesnikova & N. B. Epshtein

Authors
  1. P. A. Poluboyarinov
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  2. P. P. Leshchenko
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  3. I. Ya. Moiseeva
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  4. S. G. Kolesnikova
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  5. N. B. Epshtein
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Correspondence to P. A. Poluboyarinov.

Additional information

Original Russian Text © P.A. Poluboyarinov, P.P. Leshchenko, I.Ya. Moiseeva, S.G. Kolesnikova, N.B. Epshtein, 2017, published in Zhurnal Analiticheskoi Khimii, 2017, Vol. 72, No. 7, pp. 633–638.

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Poluboyarinov, P.A., Leshchenko, P.P., Moiseeva, I.Y. et al. Mechanism of reaction of selenium elimination in diacetophenonyl selenide under the action of reduced glutathione. J Anal Chem 72, 739–744 (2017). https://doi.org/10.1134/S1061934817070103

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  • DOI: https://doi.org/10.1134/S1061934817070103

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