Skip to main content
SpringerLink
Log in

Electrochemical methods for the determination of heparin

  • Reviews
  • Published:
Journal of Analytical Chemistry Aims and scope Submit manuscript

Abstract

A review of studies on the determination of heparin in various samples (pharmaceuticals, biological fluids) by electrochemical methods of analysis in 1976–2014 is presented. Heparin is most often determined in pharmaceuticals by polarography using cationic dyes, and in biological samples, by differential pulse methods on non-stationary mercury electrodes. Works on the creation of heparin-selective electrodes coated with a polyvinylchloride membrane with quarternary ammonium salts are most promising; they can, probably, be used for the creation of portable devices for the determination of heparin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mashkovskii, M.D., Lekarstvennye sredstva (Pharmaceuticals), Moscow: Novaya Volna, 2012, 16th ed.

    Google Scholar 

  2. Portnyagina, E.V., Klinicheskaya farmakologiya preparatov, vliyayushchikh na protsessy tromboobrazovaniya (Clinical Pharmacology of Preparations Affecting the Processes of Thrombosis), Irkutsk: Irkutsk. Gos. Med. Univ., 2011.

    Google Scholar 

  3. Emel’yanov, D.N. and Sergeev, V.S., Lek. Vestn., 2010, vol. 5, no. 7, p. 44.

    Google Scholar 

  4. Alekperov, A.F. and Aliev, A.M., Farmatsiya, 1987, vol. 36, no. 1, p. 80.

    CAS  Google Scholar 

  5. Panov, V.P. and Ovsepyan, A.M., Pharm. Chem. J., 1979, vol. 13, no. 12, p. 1285.

    Article  Google Scholar 

  6. Lakin, K.M., Pharm. Chem. J., 1985, vol. 19, no. 10, p. 672.

    Article  Google Scholar 

  7. Farmvestnik Altya, 2009, no. 7. http://miz.altai.ru/edit/farm/31. Cited May 26, 2016.

  8. Vasil’ev, A.N., Reutskaya, L.A., Baidullaeva, Sh.A., Goryachev, D.V., Gavrishina, E.V., and Niyazov, R.R., Remedium, 2014, no. 10, p. 14.

    Google Scholar 

  9. State Register of Medicinal Products. http://grls.rosminzdrav. ru/grls.aspx. Cited May 26, 2016.

  10. State Register of Medicines (September 10, 2012). http://zakonbase.ru/content/base/274796. Cited May 26, 2016.

  11. European Pharmacopeia 8.0, Council of Europe, 2014.

  12. USP Heparin Sodium Monograph, 2012.

  13. Gosudarstvennaya Farmakopeya Respubliki Belarus’. Kontrol’ kachestva farmatsevticheskikh substantsii (State Pharmacopoeia of the Republic of Belarus. Quality Control of Pharmaceutical Substances), Minsk, 2009, vol. 2.

  14. On quality control of impurities in preparations of heparin. http://docs.cntd.ru/document/902119674. Cited May 26, 2016.

  15. Sepax Technologies. http://www.sepax-tech.com. Cited May 26, 2016.

  16. Renam. http://www.renam.ru. Cited May 26, 2016.

  17. Instructions for using the reagents for the determination of heparin-thrombin clotting time. http://artmedika.com/gallery/product/1032/677_1.pdf. Cited May 26, 2016.

  18. Barbalat, Yu.A., Prikladnoi khimicheskii analiz: Prakticheskoe rukovodstvo (Applied Chemical Analysis: A Practical Guide), Shekhovtsova, T.N., Shpigun, O.A., and Popik, M.V., Eds., Moscow: Mosk. Gos. Univ., 2010.

  19. Langmaier, J., Olsak, J., Samcova, E., Samec, Z., and Trojanek, A., Electroanalysis, 2006, vol. 18, no. 2, p. 115.

    Article  CAS  Google Scholar 

  20. Langmaier, J., Olsak, J., Samcova, E., Samec, Z., and Trojanek, A., Electroanalysis, 2006, vol. 18, no. 14, p. 1329.

    Article  CAS  Google Scholar 

  21. Langmaier, J., Samcova, E., and Samec, Z., Anal. Chem., 2007, vol. 79, no. 7, p. 2892.

    Article  CAS  Google Scholar 

  22. Jan Charles Horrow, Anesth. Analg., 1985, vol. 64, no. 3, p. 348.

    Google Scholar 

  23. Yun, J.H., Fu, B., Meyerhoff, M.E., and Yang, V.C., ASAIO J., 1994, no. 40, p. 401.

    Article  Google Scholar 

  24. Yun, J.H., Lee, L., Wahr, J.A., Yang, V.C., and Meyerhoff, M.E., ASAIO J., 1995, no. 41, p. 661.

    Article  Google Scholar 

  25. Wahr, J.A., Yun, J.H., Yang, V.C., Lee, L.M., Fu, B., and Meyerhoff, M.E., J. Cardiothorac. Vasc. Anesth., 1996, vol. 10, no. 4, p. 447.

    Article  CAS  Google Scholar 

  26. Ramamurthy, N., Baliga, N., Wahr, J., Schaller, U., Yang, V.C., and Meyerhoff, M.E., Clin. Chem., 1998, vol. 44, no. 3, p. 606.

    CAS  Google Scholar 

  27. Gemme, K.L. and Bakker, E., Anal. Biochem., 2009, vol. 386, no. 2, p. 276.

    Article  Google Scholar 

  28. Harloff, M., Taraskiewicz, J., and Fotouhi, C., Perfusion, 1991, vol. 6, no. 4, p. 297.

    Article  CAS  Google Scholar 

  29. Lewinski, K., Hu. Y., Griffin, C.C., and Cox, J.A., Electroanalysis, 1997, vol. 9, no. 9, p. 675.

    Article  CAS  Google Scholar 

  30. Piech, R., Pacsoza–Bator, B., and Goleń, K., Int. J. Electrochem. Sci., 2012, vol. 7, p. 5122.

    CAS  Google Scholar 

  31. Niyati Singh, Indian J. Hematol. Blood Transfus., 2012, vol. 28, no. 2, p. 97.

    Article  Google Scholar 

  32. Electroanalytical Methods: Guide to Experiments and Applications, Sholz, F., Ed., New York: Springer, 2002.

  33. Miskidzh’yan, S.P. and Kravchenyuk, L.P., Polyarografiya lekarstvennykh preparatov: uchebnoe posobie (Polarography of Medicinal Preparations: A tutorial), Kiev: Vishcha Shkola, 1976.

    Google Scholar 

  34. Liang Tan, Shouzhuo Yao, and Qingji Xie, Talanta, 2007, vol. 71, p. 827.

    Article  CAS  Google Scholar 

  35. Vishenkova, D.A., Korotkova, E.I., and Dorozhko, E.V., Fundam. Issled., 2013, nos. 8–3, p. 561.

    Google Scholar 

  36. Hong Yu Huo, Hong Qun Luo, and Nian Bing Li, Microchim. Acta, 2009, vol. 167, no. 3, p. 195.

    Article  CAS  Google Scholar 

  37. Wei Sun, Yaqin Ding, Qingxiang Wang, and Kui Jiao, Electroanalysis, 2006, vol. 18, no. 11, p. 1114.

    Article  CAS  Google Scholar 

  38. Sun Wei, Ding Ya-Qin, and Jiao Kui, Chem. Res. Chin. Univ., 2006, vol. 22, no. 3, p. 406.

    Article  Google Scholar 

  39. Ni Hui, Wei Sun, and Ya-Qin-Ding, J. Chin. Soc., 2009, vol. 56, p. 271.

    Article  CAS  Google Scholar 

  40. Xueliang Niu, Wie Sun, Na Zhao, Kui Jiao, Indian J. Chem. Technol., 2008, vol. 15, p. 476.

    CAS  Google Scholar 

  41. Xueliang Niu, Wieli Zhang, Na Zhao, and Wie Sun, Bull. Chem. Soc. Ethiop., 2008, vol. 22, no. 2, p. 172.

    Article  Google Scholar 

  42. Sun Wei, Jiao Kui, Junying Han, and Lude Lu, Anal. Lett., 2005, vol. 38, p. 1137.

    Article  Google Scholar 

  43. Sun Wei, Ding Yaqin, and Jiao Kui, J. Anal. Chem., 2006, vol. 61, no. 4, p. 359.

    Article  Google Scholar 

  44. Vishenkova, D.A., Korotkova, E.I., and Dorozhko, E.V., Adv. Mater. Res., 2014, vol. 1040, p. 292.

    Article  Google Scholar 

  45. Xiu Ying Peng, Hong Qun Luo, and Nian Bing Li, Microchim. Acta, 2007, vol. 156, p. 297.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Natural Resources, National Research Tomsk Polytechnic University, Tomsk, 634050, Russia

    D. A. Vishenkova & E. I. Korotkova

Authors
  1. D. A. Vishenkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. I. Korotkova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. A. Vishenkova.

Additional information

Original Russian Text © D.A. Vishenkova, E.I. Korotkova, 2017, published in Zhurnal Analiticheskoi Khimii, 2017, Vol. 72, No. 4, pp. 291–295.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vishenkova, D.A., Korotkova, E.I. Electrochemical methods for the determination of heparin. J Anal Chem 72, 349–353 (2017). https://doi.org/10.1134/S1061934817040153

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1061934817040153

Keywords

Search

Navigation