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Voltammetric determination of nitrendipine on composite film modified electrode

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Abstract

This paper was focused on the use of electrochemical methods based on a novel composite film modified electrode for the pharmaceutical analysis. This modified electrode was fabricated by integration of room-temperature ionic liquids (1-butyl-3-methylimidazolium hexafluophosphate) and multi-walled carbon nanotubes with polymeric matrix (chitosan). This sensor showed good stability and high accumulation efficiency. Electrochemical behavior of nitrendipine at this electrode was investigated in detail. A sensitive cathodic peak was observed at −0.76 V on the modified electrode. Under the optimized conditions, the peak current was linear to nitrendipine concentration in the range of 4.0 × 10−7 ∼ 5.0 × 10−5 M, and the detection limit was estimated to be 1.0 × 10−7 M after an accumulation for 150 s on open circuit. In addition, the proposed method was applied to the determination of nitrendipine in real samples, and the recovery was from 97.6 to 102.5%.

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Authors and Affiliations

  1. Department of Environment Engineering and Chemistry, Luoyang Institute of Science and Technology, Luoyang, 471023, P.R. China

    Yingliang Wei & Lan Zhang

  2. Department of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou, 450002, P.R. China

    Luping Zhang, Chen Shao & Chao Li

Authors
  1. Yingliang Wei
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  2. Lan Zhang
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  3. Luping Zhang
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  4. Chen Shao
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  5. Chao Li
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Wei, Y., Zhang, L., Zhang, L. et al. Voltammetric determination of nitrendipine on composite film modified electrode. J Anal Chem 66, 969–973 (2011). https://doi.org/10.1134/S1061934811100169

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  • DOI: https://doi.org/10.1134/S1061934811100169

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