Abstract
Four adsorbents were synthesized by immobilizing a chiral selector, heptakis(6-amino-6-deoxy)-β-cyclodextrin, on different silica matrices, such as LiChrosorb Si 100, 10 μm; Silasorb SPH Amin, 5 μm; Kromasil 100-5-Sil, 5 μm; and Kromasil 300-5-Sil, 5 μm. The surface of adsorbents was examined by low-temperature nitrogen adsorption, and the structural properties of substrates and adsorbents were studied by electron microscopy. A matrix effect on the enantiorecognition ability of adsorbents was studied in the reversed-phase and polar-organic modes of high performance liquid chromatography using some amino acid derivatives (N-carbobenzyloxy-and tert-butoxycarbonyl-) and profens as examples. The adsorbent based on Kromasil 100-5-Sil possesses the best chromatographic properties. It was shown that the enantiomeric composition and the concentration of the active component in Ibuprofen can be determined.
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Original Russian Text © E.V. Potekhina, I.A. Anan’eva, E.N. Shapovalova, S.A. Lopatin, V.P. Varlamov, O.A. Shpigun, 2007, published in Zhurnal Analiticheskoi Khimii, 2007, Vol. 62, No. 2, pp. 128–137.
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Potekhina, E.V., Anan’eva, I.A., Shapovalova, E.N. et al. Matrix effect on the enantiorecognition ability of adsorbents based on heptakis(6-amino-6-deoxy)-β-cyclodextrin. J Anal Chem 62, 113–121 (2007). https://doi.org/10.1134/S1061934807020037
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DOI: https://doi.org/10.1134/S1061934807020037