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Genetic Diversity of North Eurasia Populations by Genetic Markers Associated with Diseases Impairing Human Cognitive Functions

  • HUMAN GENETICS
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Abstract

The genetic diversity of sixteen native populations of North Eurasia is investigated using a panel of genetic markers in genes associated, according to the data of genome-wide association studies, with diseases that lead to impaired human cognitive functions (schizophrenia, Alzheimer’s disease, and their cognitive endophenotypes). There is a decrease in genetic diversity in the geographic space from west to east. The highest level of genetic diversity was shown in Caucasoid populations. There are two groups of SNPs that predominate in Caucasians or Mongoloids. The location of sixteen populations in the space of the principle components demonstrates their geographic localization. Clusterization of populations in accordance with their affiliation to four geographic regions was observed. In general, the analysis of within- and between-population genetic diversity for 28 markers in 16 populations replicates the patterns of the Northern Eurasia gene pool structure, which are described using other marker systems.

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Funding

The present study was supported by the Russian Foundation for Basic Research (project no. 18-29-13045).

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  1. Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050, Tomsk, Russia

    A. V. Bocharova & V. A. Stepanov

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  1. A. V. Bocharova
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Correspondence to A. V. Bocharova.

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by A. Kazantseva

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Bocharova, A.V., Stepanov, V.A. Genetic Diversity of North Eurasia Populations by Genetic Markers Associated with Diseases Impairing Human Cognitive Functions. Russ J Genet 57, 1082–1091 (2021). https://doi.org/10.1134/S1022795421080020

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