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Oxygen-Dependent Adaptation Processes in a Human Organism in Normal Living Conditions and during Space Flight

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Abstract

The review examines various parties of oxygen-dependent human adaptation to microgravity belonging to different levels of the integral system organization. Particular emphasis is placed on the cellular sensor-based systems of immediate and chronic reactions to altered O2 delivery. The authors describe the key oxygen sensors and heterogeneity of the oxygen-sensing mechanisms. Under consideration also is the role of O2 active forms and O2-sensing elements developing in the spaceflight (SF) environment. The first experimental data on an increase in the frequency of oxidative post-translational modifications of proteins caused by SF factors are presented. A hypothesis is proposed about the direction and possible systemic mechanisms of oxygen-dependent adaptation of the human body during SF.

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Funding

This study was supported by the Program for Fundamental Research of the State Scientific Center of the Russian Federation, Institute of Biomedical Problems, Russian Academy of Sciences, topic 65.3.

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    I. M. Larina, L. B. Buravkova & A. I. Grigoriev

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  1. I. M. Larina
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Correspondence to I. M. Larina.

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Translated by A. Deryabina

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Larina, I.M., Buravkova, L.B. & Grigoriev, A.I. Oxygen-Dependent Adaptation Processes in a Human Organism in Normal Living Conditions and during Space Flight. Hum Physiol 48, 838–850 (2022). https://doi.org/10.1134/S0362119722070118

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