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Tantalum-Containing Bioactive Glass-Ceramics: A Mechanism of Suppression of the Biological Activity of the 45S5 Bioglass by Doping with Ta2O5

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Abstract

Methods for the synthesis of radiopaque tantalum-containing glass and glass-ceramics by doping 45S5 bioglass with tantalum oxide are presented. Bioactive glass has been obtained by pyrolysis of a mixture of organic precursors: tetraethoxysilane, tributyl phosphate, sodium oleate, and calcium oleate. Bioglass has been doped with tantalum oxide by three different methods. The mechanism of suppression of the biological activity of materials with an increase in the Ta2O5 content has been studied. The bioactivity of samples containing 1–40 wt % Ta2O5 has been evaluated in vitro using a model medium—an SBF solution. The samples have been studied by 31P NMR, XRD, SEM, and EDS. A decrease in the concentration of calcium in the glass phase due to the formation of insoluble CaTa2O6 crystals has been considered the major cause of the suppression of the bioactivity of glasses. Samples containing up to 10 wt % Ta2O5 can be used in modern medicine as materials that restore bone tissue. The radiopaque substance in the composition of the biomaterial makes it possible to monitor the process of bone tissue regeneration. Samples containing more than 20 wt % Ta2O5 failed in vitro tests. Due to the dissolution of one of the phases of glass-ceramics in a model solution, the prognosis for the use of such materials in vivo is unfavorable.

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Funding

The work was partially supported by the Program for Basic Research of the Far Eastern Branch of the RAS “Far East” (project no. 18-3-042) and in the framework of the Sate Assignment for the Institute of Chemistry, Far Eastern Branch, RAS (project no. 0265-2018-0002).

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Authors and Affiliations

  1. Institute of Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022, Vladivostok, Russia

    D. N. Grishchenko, A. B. Slobodyuk, V. G. Kuryavyi & M. A. Medkov

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  1. D. N. Grishchenko
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  2. A. B. Slobodyuk
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  3. V. G. Kuryavyi
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  4. M. A. Medkov
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Correspondence to D. N. Grishchenko.

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Translated by G. Kirakosyan

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Grishchenko, D.N., Slobodyuk, A.B., Kuryavyi, V.G. et al. Tantalum-Containing Bioactive Glass-Ceramics: A Mechanism of Suppression of the Biological Activity of the 45S5 Bioglass by Doping with Ta2O5 . Russ. J. Inorg. Chem. 65, 1606–1613 (2020). https://doi.org/10.1134/S0036023620100083

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  • DOI: https://doi.org/10.1134/S0036023620100083

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