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Association of polymorphisms in the toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan

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Abstract

Atopic dermatitis is a common chronic inflammatory skin disease and depends on the interaction between environmental factors and genetic predisposition. A considerable role in allergic disorders is played by polymorphisms of the genes of pattern recognition receptors (PRRs), which recognize conserved standard molecular structures (patterns) unique to large pathogen groups. Polymorphisms of several PRR genes, including the genes of Toll-like receptors (TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, and TLR10), NOD-like receptors (NOD1 and NOD2), and a lipopolysaccharide receptor (CD14) along with C11orf30 and LRRC32 from chromosome 11q13.5, were studied in atopic dermatitis patients and control subjects from Bashkortostan. TLR1 (rs5743571 and rs5743604), TLR6 (rs5743794), and TLR10 (rs11466617) polymorphisms were associated with atopic dermatitis. The results supported the idea that innate immunity and polymorphisms of the TLR2-family genes play a substantial role in atopic dermatitis.

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Abbreviations

PRR:

pattern recognition receptor

FLG:

filaggrin gene

TLR:

Toll-like receptor

NLR:

NOD-like receptor

CLR:

C-type lectin receptor

LRRC32:

leucine-rich repeatcontaining protein 32

C11orf30 (chromosome 11 open reading frame 30, EMSY):

EMSY transcriptional regulator

GWAS:

genome-wide association study

SNP:

single-nucleotide polymorphism

OR:

odds ratio

FDR:

false discovery rate

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Authors and Affiliations

  1. Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, 450054, Russia

    G. F. Gimalova, A. S. Karunas, Yu. Yu. Fedorova & E. K. Khusnutdinova

  2. Bashkir State University, Ufa, 450074, Russia

    A. S. Karunas & E. K. Khusnutdinova

  3. Dermatovenerological Dispensary of the Republic of Bashkortostan, Ufa, 450027, Russia

    E. R. Gumennaya

  4. Bashkir State Medical University, Ufa, 450000, Russia

    S. V. Levashova, Z. R. Khismatullina & E. I. Etkina

  5. University of Tartu, Tartu, 50411, Estonia

    E. Prans & S. Kõks

Authors
  1. G. F. Gimalova
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  2. A. S. Karunas
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  3. Yu. Yu. Fedorova
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  4. E. R. Gumennaya
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  5. S. V. Levashova
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  6. Z. R. Khismatullina
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  8. S. Kõks
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  9. E. I. Etkina
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  10. E. K. Khusnutdinova
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Correspondence to G. F. Gimalova.

Additional information

Original Russian Text © G.F. Gimalova, A.S. Karunas, Yu.Yu. Fedorova, E.R. Gumennaya, S.V. Levashova, Z.R. Khismatullina, E. Prans, S. K ks, E.I. Etkina, E.K. Khusnutdinova, 2014, published in Molekulyarnaya Biologiya, 2014, Vol. 48, No. 2, pp. 265–276.

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Gimalova, G.F., Karunas, A.S., Fedorova, Y.Y. et al. Association of polymorphisms in the toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan. Mol Biol 48, 227–237 (2014). https://doi.org/10.1134/S002689331402006X

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  • DOI: https://doi.org/10.1134/S002689331402006X

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