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Three patterns of trypanosomatid cryptogene structural organization

  • Genomics. Transcriptomics
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Abstract

The structures of some cryptogenes of previously unstudied species of homoxenous trypanosomatids that belong to different phylogenetic groups has been analyzed. New examples of the editing domain length reduction for A6 and COIII were found. A comparative analysis of the sequences allowed us to divide the cryptogenes into three groups (patterns) according to not only the evolutionary variations in the length of the edited domain, but also the degree of conservation of the nucleotide sequence. The potential factors that determine variants of the cryptogene structure are discussed. In addition, the alternative editing of the rps12 transcript of Wallaceina sp. Wsd has been demonstrated.

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Abbreviations

AE:

alternative editing

ED:

edited domain

gRNA:

guide RNA

ORF:

open-reading frame

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Authors and Affiliations

  1. Moscow State University, Moscow, 119992, Russia

    E. S. Gerasimov, N. S. Efimova & A. A. Kolesnikov

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  1. E. S. Gerasimov
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  2. N. S. Efimova
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  3. A. A. Kolesnikov
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Correspondence to E. S. Gerasimov.

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Original Russian Text © E.S. Gerasimov, N.S. Efimova, A.A. Kolesnikov, 2012, published in Molekulyarnaya Biologiya, 2012, Vol. 46, No. 4, pp. 612–621.

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Gerasimov, E.S., Efimova, N.S. & Kolesnikov, A.A. Three patterns of trypanosomatid cryptogene structural organization. Mol Biol 46, 548–556 (2012). https://doi.org/10.1134/S0026893312040036

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