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T5 Group Bacteriophages as Potential Phage Therapy Agents

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Abstract—

The T5 group bacteriophages, which infect a number of enterobacterial species and strains, are useful objects for obtaining therapeutic phage preparations with broad specificity. The present work considers the biological properties of T5-related phages responsible for their ability to infect a broad spectrum of bacterial strains in spite of a limited number of known phage receptor proteins. Ability of bacteriophages to recognize bacterial O-antigens specifically enhances their capacity for infection and increases the therapeutic potential of the T5 phages.

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Funding

The work to determine the spectrum of host strains of the Proteus spp. bacteriophage PM135 was performed as part of the project no. 18-29-08015, Russian Foundation for Basic Research. The search and research for new hosts for the DT57C/DT571/2 and Gostya9 coliphages was supported by the Russian Science Foundation, project no. 15-15-00134P.

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Authors and Affiliations

  1. Winogradsky Institute of Microbiology, Research Center of Biotechnology, Russian Academy of Sciences, 119071, Moscow, Russia

    E. E. Kulikov, A. K. Golomidova & A. V. Letarov

  2. Moscow State University, 119192, Moscow, Russia

    A. V. Letarov

  3. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    V. V. Morozova & Yu. N. Kozlova

Authors
  1. E. E. Kulikov
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  2. A. K. Golomidova
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  3. V. V. Morozova
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  4. Yu. N. Kozlova
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  5. A. V. Letarov
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Corresponding author

Correspondence to A. K. Golomidova.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by E. Babchenko

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Kulikov, E.E., Golomidova, A.K., Morozova, V.V. et al. T5 Group Bacteriophages as Potential Phage Therapy Agents. Microbiology 88, 769–772 (2019). https://doi.org/10.1134/S0026261719060067

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  • DOI: https://doi.org/10.1134/S0026261719060067

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