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Experimental Zebrafish Models of Synaptopathies

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Abstract

Synaptopathies represent a heterogeneous group of severe, debilitating neurological diseases characterized by structural and functional synaptic deficits. Common synaptopathies include epilepsy, schizophrenia, prion diseases, autism spectrum disorders, various autoimmune diseases, and cochlear synaptopathies. Their pathogenesis is caused by both genetic and environmental factors. However, the relationship between the cause and clinical manifestations of each particular synaptopathy, as well as their therapy, remain poorly understood. Here, we discuss animal models of synaptopathies with a special focus on zebrafish (Danio rerio) and outline several lines of future research in this field. Overall, the zebrafish emerges as a promising organism to mimic a wide range of synaptopahies, paralleling and complementing their existing models in rodents.

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Funding

This work was supported by Almazov National Medical Research Center (St. Petersburg).

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Authors and Affiliations

  1. Almazov National Medical Research Center, St. Petersburg, Russia

    A. S. Lebedev, N. P. Ilyin, D. S. Galstyan & A. V. Kalueff

  2. Research Center for Genetics and Life Sciences, Sirius University of Science and Technology, Sochi, Russia

    A. S. Lebedev, M. M. Kotova, T. O. Kolesnikova & A. V. Kalueff

  3. Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia

    A. S. Lebedev, N. P. Ilyin, D. S. Galstyan & A. V. Kalueff

  4. Granov Russian Research Center for Radiology and Surgical Technologies, St. Petersburg, Russia

    D. S. Galstyan & A. V. Kalueff

  5. Moscow Institute of Physics and Technology, Moscow, Russia

    E. V. Petersen

  6. Ural Federal University, Yekaterinburg, Russia

    A. V. Kalueff

  7. Institute of Molecular Genetics, National Research Center “Kurchatov Institute”, Moscow, Russia

    T. V. Vyunova

Authors
  1. A. S. Lebedev
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  2. M. M. Kotova
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  3. T. O. Kolesnikova
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  4. N. P. Ilyin
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  5. D. S. Galstyan
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  6. T. V. Vyunova
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  7. E. V. Petersen
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  8. A. V. Kalueff
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Contributions

Conceptualization, supervision, project coordination (A.V.K.), writing a draft (A.S.L., M.M.K.), concept discussion, editing a manuscript (A.V.K., N.P.I., A.S.L., M.M.K., D.S.G., T.О.K., T.V.V., E.V.P.).

Corresponding author

Correspondence to A. V. Kalueff.

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ETHICS APPROVAL AND CONSENT TO PARTICIPATE

This work does not contain any studies involving human and animal subjects.

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest related to the publication of this article.

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Translated by A. Polyanovsky

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Russian Text © The Author(s), 2023, published in Rossiiskii Fiziologicheskii Zhurnal imeni I.M. Sechenova, 2023, Vol. 109, No. 11, pp. 1601–1616https://doi.org/10.31857/S0869813923110092.

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Lebedev, A.S., Kotova, M.M., Kolesnikova, T.O. et al. Experimental Zebrafish Models of Synaptopathies. J Evol Biochem Phys 59, 2101–2113 (2023). https://doi.org/10.1134/S0022093023060169

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  • DOI: https://doi.org/10.1134/S0022093023060169

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